Results 101 to 110 of about 7,265,756 (310)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Minutes: Educational Policy Committee, September 10, 2008

, 2008
University of Minnesota Duluth. Educational Policy Committee. (2008). Minutes: Educational Policy Committee, September 10, 2008.
University of Minnesota Duluth. Educational Policy Committee
core  

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

Minutes: Educational Policy Committee, April 12, 2006

, 2006
University of Minnesota Duluth. Educational Policy Committee. (2006). Minutes: Educational Policy Committee, April 12, 2006.
University of Minnesota Duluth. Educational Policy Committee
core  

Enhancing Quality Appointment, Preparation and Support System for Malaysian Principals

Education Sciences
Educational leaders in the 21st century are under increasing pressure since they need to consistently upskill and reskill themselves so that they can adapt to rapid changes and be prepared to improve the quality of future education, as well as meet the ...
Husaina Banu Kenayathulla, Muhammad Faizal A. Ghani, Norfariza Mohd Radzi   +2 more
doaj   +1 more source

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Minutes: Educational Policy Committee, November 12, 1997

, 1997
University of Minnesota, Duluth. Educational Policy Committee. (1997). Minutes: Educational Policy Committee, November 12, 1997.
University of Minnesota, Duluth. Educational Policy Committee
core  

From Perceived Organizational Support to Employee Creativity: Mediating Role of Affective Commitment

Journal of Social Sciences and Humanities
Employee creativity is important for innovation and performance in organizations, but how this creativity is encouraged in higher education institutions is not well understood.
Mujeeb Rahman Rahmani, Sayed Sami Muzafary, Mohammad Farid Noorzad   +2 more
doaj   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Minutes: Educational Policy Committee, November 19, 2003

, 2003
University of Minnesota Duluth. Educational Policy Committee. (2003). Minutes: Educational Policy Committee, November 19, 2003.
University of Minnesota Duluth. Educational Policy Committee
core