Results 111 to 120 of about 25,046,336 (346)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Политика образования в Сирии: обзор [PDF]

, 2017
В статье рассматриваются особенности системы образования в Сирии, политики, формирующей этапы учебного процесса и основные характеристики иерархической структуры сирийского образования.This paper provides an insight to the educational system in Syria ...
Atieh, B.
core  

Enhancing skills of critical reflection to evidence learning in professional practice [PDF]

, 2013
Professional organisations and regulatory bodies are making critical reflection a mandatory component of professional practice. Reflection is a vital part of learning from experience and is central to developing and maintaining competency across a ...
Benner, Biesta, Biesta, Bulley, Colin Paterson, Donaghy, Dreyfus, Duffy, Erben, Ertmer, Gadamer, Ghaye, Gibbs, Habermas, Higgs, Jasper, Jensen, Johns, Jones, Judith Chapman, King, Kolb, Mann, Mezirow, Moon, Moon, Ricoeur, Rivett, Roberts, Rolfe, Rolfe, Schön, Schön   +32 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The Mediating Role of Job Satisfaction Between Leadership and Organizational Performance and the Moderating Effect of Educational Context [PDF]

Educational Process: International Journal
Background/purpose. Leadership behaviors correlate with job satisfaction, which is supposed to have impact on overall organizational performance. This study aimed to establish a model to explain organizational performance by determining the relational ...
Fahrettin Gılıç , Sedat Kanadlı , Yüksel Gündüz , Yusuf İnandı
doaj   +1 more source

Educational Process and Personality of the Educator [PDF]

Acta Technologica Dubnicae, 2012
Abstract The paper is focused on the personality of an educator and the demands placed on him/her.
Lenka Pasternáková, Gabriela Sláviková   +1 more
openaire   +1 more source

Technology in the educational process: New scenario

, 2020
Technology in the educational process, today represents an essential and essential tool, being a requirement of modern life, which is radically incorporated in a mandatory confinement product of the pandemic caused by the SARS 2 virus that is called ...
Granados Maguiño, Mauro Amaru, Romero Vela, S. Lidia, Rengifo Lozano, Raúl Alberto, Garcia Mendocilla, G. Fernando   +7 more
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source