Results 51 to 60 of about 3,258,851 (300)

YourMOOC4all: a MOOCs inclusive design and useful feedback research project [PDF]

, 2018
User feedback can be of great value for the development of guidelines to design MOOC platforms, courses, and open educational resources. Considering other learners’ experiences may benefit the development of course recommender systems that consider not ...
Iniesto, Francisco, Rodrigo, Covadonga
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Automatic generation of audio content for open learning resources [PDF]

, 2009
This paper describes how digital talking books (DTBs) with embedded functionality for learners can be generated from content structured according to the OU OpenLearn schema.
Brasher, Andrew, McAndrew, Patrick
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Using a novel multiple-source indicator to investigate the effect of scale format on careless and insufficient effort responding in a large-scale survey experiment

Large-scale Assessments in Education
Common indicator-based approaches to identifying careless and insufficient effort responding (C/IER) in survey data scan response vectors or timing data for aberrances, such as patterns signaling straight lining, multivariate outliers, or signals that ...
Esther Ulitzsch, Janine Buchholz, Hyo Jeong Shin, Jonas Bertling, Oliver Lüdtke   +4 more
doaj   +1 more source

Educational Backgrounds and Youth Criminality in Nigeria [PDF]

, 2009
Mismanagement and recurring strikes in the Nigerian educational sector have institutionalized a legacy of intellectual poverty and criminality among youth. Unchecked persistent strikes have led to progressive deterioration in infrastructure and academic
Egwakhe, A. J., Osabuohien, E. S. C.
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Wanted: A vocabulary for talking about involuntary behaviors associated with Lesch‐Nyhan disease

JIMD Reports, 2021
Lesch‐Nyhan disease (LND) is a rare genetic disorder with an unusual behavioral phenotype that includes severe and involuntary self‐injury requiring the near constant use of protective devices and, for some individuals, dental extraction.
Kenneth L. Robey, Daniel C. Balboni
doaj   +1 more source

Building a Healthier Louisville [PDF]

, 2013
For more than a decade, the Greater Louisville Project has provided research and data to catalyze civic action. By highlighting progress and challenges in three Deep Drivers of Change -- Education, 21st Century Jobs, and Quality of Place -- the GLP has ...

core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source