Results 141 to 150 of about 1,969,731 (269)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Linking teachers’ personal practice and theories on teaching: using multi-method triangulation for examing teachers knowledge [PDF]

open access: yes, 2010
Object: This study presents a collective case study design and multi-method triangulation as a method for research on teachers’ knowledge and classroom practice, in particular the study of how in-service teachers view their teaching, and how teachers use
GOLA, GIANCARLO
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Leadership trends in institutions of Higher Education: A bibliometric review

open access: yesRevista de Ciencias Sociales
This Investigation aims to analyze scientific production and thematic trends in the field of leadership in institutions of higher education. This is a documentary type review which seeks to shows how a bibliometric analysis of the Web of Science database
Wendolin Suárez-Amaya   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Monitoring trends in educational growth: a partnership service to monitor the educational growth of students in the early to middle years of schooling [PDF]

open access: yes, 2014
MTEG is a service that involves ACER staff working closely with each country to develop an assessment program that meets the country’s monitoring needs while being based as closely as possible on a set of defined design principles and quality standards.
Australian Council for Educational Research (ACER)   +1 more
core   +2 more sources

Awareness, knowledge, and utilisation of online digital tools for literature review in educational research. [PDF]

open access: yesHeliyon, 2023
Alordiah CO   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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