Results 41 to 50 of about 7,610,845 (255)

Obstacles of education in the context of Surah Mubaraka Juma [PDF]

اخلاق وحیانی
In Surah Juma, the main indicators of the revealed education system are depicted. In this surah, the foundations, obstacles of education and the results of education can be analyzed as the components of the education system.
Abdolkarim Abedini, Ali Habati nejad
doaj   +1 more source

A Study of the Usefulness of Physical Models and Digital Models for Teaching Science to Prospective Primary School Teachers

Education Sciences, 2023
This study focuses on the impact of the use of teaching resources on future teachers in different formats, physical and digital. We worked with a single task dealing with nutrition in humans with two groups of students, but one group worked with a ...
F. Javier Robles-Moral, Manuel Fernández-Díaz, Gabriel Enrique Ayuso-Fernández   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spotlight on OER policy in the Global South: Case studies from the Research on Open Educational Resources for Development (ROER4D) project

, 2017
To understand how policies enable or constrain educators’ adoption of Open Educational Resources (OER) in South America, Sub-Saharan Africa and South and Southeast Asia, the Research on Open Educational Resources for Development (ROER4D) project ...
Research on Open Educational Resources for Development (ROER4D) project
core   +1 more source

An Integrated K-Means++–Davies–Bouldin Index Approach for Educational Resource-Based District Clustering: A Case Study of Districts in Surabaya

Jambura Journal of Mathematics
Equitable distribution of educational resources is an important prerequisite to ensure that all communities benefit from human resource development. Access to education through the availability of schools and teachers at every level, plays a role in ...
Hendrik Subaekti, Lutfi Hakim, Hani Khaulasari, Dian Yuliati   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Teachers' Challenges in Implementing Inclusive Education Amid Crisis

EDUCATIO: Journal of Education
This study explores the challenges teachers faced in implementing inclusive education amid crises, using the COVID-19 pandemic as a case study. An interpretive research paradigm was adopted, emphasizing participants' experiences over theoretical ...
Maryam Chinasa Adewunmi
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source