Results 51 to 60 of about 7,610,845 (255)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The Educational Semantic Web: Visioning and Practicing the Future of Education

Journal of Interactive Media in Education, 2004
: I (Terry) first became interested in the semantic web from reading Berners-Lee's original works and following first generation developments of semantic web technologies in information science, e-business and health fields. I then began including the
Terry Anderson, Denise M. Whitelock
doaj   +1 more source

Where Comics and Cultural Heritage Meet: A Conversation with Damien Sueur and Yannis Koikas on BDnF: The Comics Factory

The Comics Grid: Journal of Comics Scholarship, 2020
The Bibliothèque nationale de France (BnF; French National Library) recently launched a free comics creation desktop and mobile application, “BDnF”. Designed and produced by the BnF, BDnF is a digital creation tool for making comics and other multimedia ...
Ernesto Priego, Stuart Scott
doaj   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Ownership and Usage of Mobile Devices Among Ophthalmology Residents and Attending Physicians: Identifying the Generation Gap

Advances in Medical Education and Practice, 2020
Adi Mohammed Al Owaifeer,1,2 Abdulaziz Al Taisan,1 Bader Alqahtani,3 Khalid Alburayk,4 Majed Alsubaie,5 Saad H Alenezi6 1Faculty of Ophthalmology, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia; 2King Khaled Eye Specialist Hospital ...
Al Owaifeer AM, Al Taisan A, Alqahtani B, Alburayk K, Alsubaie M, Alenezi SH   +5 more
doaj  

Fonctionnements et trajectoires des réseaux professionnels en ligne : le cas des réseaux d’enseignants

Distances et Médiations des Savoirs, 2014
Digital technologies facilitate the creation of networks focused on connecting people. They allow users to create, mix and easily share informative contents and therefore support the development of on-line networks with the objective of sharing knowledge
Isabelle Quentin
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Enseñanza y difusión sobre el uso de recursos educativos abiertos con MOOC: un estudio de caso

CPU-e, 2018
El presente artículo analiza el caso de un Curso en Línea Masivo y Abierto (MOOC) que tiene por objetivo desarrollar competencias digitales y de diseño instruccional para integrar Recursos Educativos Abiertos (REA) en ambientes de aprendizaje. Se utiliza
Martín Alonso Mercado Varela, Katiuska Fernández Morales, Gilles Lavigne, María Soledad Ramírez Montoya   +3 more
doaj  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Nursing students’ experiences with the “DiagNurse” mobile app to support clinical patient assessment – a pilot study

Pielęgniarstwo XXI Wieku
NURSING STUDENTS’ EXPERIENCES WITH THE “DIAGNURSE” MOBILE APP TO SUPPORT CLINICAL PATIENT ASSESSMENT – A PILOT STUDY Aim. This study aimed to investigate how nursing students utilised the “DiagNurse” mobile app to assess patient health conditions ...
Barbara Ślusarska, Agnieszka Chrzan-Rodak, Aneta Bernadeta Jędrzejewska, Monika Bieniak-Czerepak, Wiktoria Mazurek, Alicja Waśkowicz, Grzegorz Józef Nowicki   +6 more
doaj   +1 more source