Results 41 to 50 of about 229,069 (263)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Metatheoretical Foundations of Educational Theory. Selected Aspects [PDF]

Studia z Teorii Wychowania
This article presents metatheoretical analyses. Their subject is educational theory, while the aim is to formulate descriptive metatheoretical remarks on selected aspects of the functioning of educational theory as a sub-discipline of pedagogical science.
Piotr Magier
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Middle-Level Teacher Development and Identity: A Review of the Literature

Education Sciences
Historically, the field of middle-level education has taken it as a given that teachers of young adolescents should be specially prepared to teach in the middle grades, developing a teacher identity that centers around responding to and advocating for ...
P. Gayle Andrews, Alyson Leigh Wright
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Research and Praxis On Challenging Anti-immigration Discourses in School and Community Contexts

Norteamérica, 2013
Recently, harsh immigration policies have made the lives of the new immigrant Diaspora in the southeastern United States extremely challenging. Disturbed by the impact of these sociopolitical changes on students, their families, and their teachers, as ...
Martha Allexsaht-Snider, Cory A. Buxton, Ruth Harman   +2 more
doaj  

Etnoeducación: alternativa educativa vs. Etnoeducación enfoque educativo. In memoriam del Dr. Francisco Justo Pérez van-Leenden

Entretextos, 2021
En el análisis de los textos, se advierte que, muchos trabajos acerca de la llamada etnoeducación, no han visto el mundo como éste ha sido develado por las reglas de la cultura procedentes de las interacciones sociales de sus actores, sino cómo aquella ...
Mario Hoyos Benítez
doaj  

Some Thoughts on Philosophy of Education

Філософія освіти, 2017
Philosophy of education is usually understood as a special branch of philosophy. However, a noteworthy fact is that in many countries philosophy of education is not recognized as such and, consequently, is not taught in departments of philosophy, but ...
Zdenko Kodelja
doaj   +1 more source