Results 61 to 70 of about 229,069 (263)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The roles and uses of design principles for developing the trialogical approach on learning

Research in Learning Technology, 2011
In the present paper, the development and use of a specific set of pedagogical design principles in a large research and development project are analysed. The project (the Knowledge Practices Laboratory) developed technology and a pedagogical approach to
Kari Kosonen, Hanni Muukkonen, Minna Lakkala, Sami Paavola, Klas Karlgren   +4 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Aesthetic Mediation: The Formation of Practitioner–Researcher–Scholar Identity and Artistry in HE-Supported Vocational Research

Education Sciences
The failure of top-down approaches to education policy in England draws attention to the importance of context and foregrounds the need to help teachers to see themselves as practitioner–researchers, scholars and researchers capable of conducting ...
Daniel Gregson
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

J. S. Bruner認知理論之歷史發展與教育理論內涵─以J. M. Anglin編選文集（1945-1972）為基礎 The Historical Development and Educational-Theoretical Foundations of J. S. Bruner’s Cognitive Theory: A Study Based on J. M. Anglin’s Selected Works (1945-1972)

Journal of Research in Education Sciences
本研究聚焦J. S. Bruner於1945-1972年間的認知研究發展，並依其所發表之作品為文獻分析基礎，嘗試從教育理論的視野出發，建構一套以「認知」、「發展」與「教育」為核心向度的研究分類架構，以梳理Bruner各時期著作之整體脈絡與理論連貫性。研究結果顯示，Bruner早期即專注於知覺與思考歷程的探究，並以此作為改進教育實務與推動教育改革的重要理論基礎，其間亦持續將心理學研究成果轉化為教育理論資源。在理論內涵方面，Bruner的教育思維可歸納為以下要點：知覺乃一種主動建構的活動 ...
顏于智 Yu-Chih Yen
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The Social Making of Educational Theory: Unraveling How to Understand the Content, Emergence, and Transformation of Educational Theory

Nordic Journal of Educational History, 2014
This article discusses the study of educational theories and ideas. Based on analyses of primarily the Danish scene, positing similarities with the other Nordic countries, we identify and investigate three main and today dominating approaches: a ...
Christian Sandbjerg Hansen, Trine Øland
doaj   +1 more source

Theory of educational forms of education: an unwritten chapter in Polish theory of education

Studia z Teorii Wychowania
In the article attention is drawn to fact that, opposite to the others extracted contents of a structure of educational process, such as educational values, aims, situations, relations and methods, in Polish theory of education the issue of an educational forms has no complex theoretical development in comparison to proposal presented in the 80s of the
openaire   +2 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source