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Scophthalmus maximus interleukin-1β limits Edwardsiella piscicida colonization in vivo

Fish & Shellfish Immunology, 2019
Interleukine-1β (IL-1β) is the first identified pro-inflammatory cytokine, which is cleaved by caspase-1 following the inflammasomes activation, playing critical roles in innate immunity. However, few studies have been performed to characterize the IL-1β in lower vertebrates.
Shouwen Chen   +5 more
openaire   +2 more sources

Requirement of innate immunity in resistance to Edwardsiella piscicida infection in medaka

Fish & Shellfish Immunology
Edwardsiella piscicida is a potent intracellular pathogen that infects a wide variety of freshwater and marine fish, causing systemic hemorrhagic sepsis that results in lethality. Although vaccines against E. piscicida have been developed for many fish species, a direct comparison between innate and adaptive immunity in protecting fish from E ...
Hiyori Sakaguchi   +2 more
openaire   +2 more sources

Balanced role of T3SS and T6SS in contribution to the full virulence of Edwardsiella piscicida

Fish & Shellfish Immunology, 2019
Edwardsiella piscicida is an important pathogen that infects a wide range of hosts, from fish to human. Its infection leads to extensive losses in a diverse array of commercially important fish, like Japanese flounder, turbot, and tilapia. During the infection, type III secretion system (T3SS) and type VI secretion system (T6SS) of E.
Tianjian Hu   +7 more
openaire   +2 more sources

Characterization of the Japanese flounder NLRP3 inflammasome in restricting Edwardsiella piscicida colonization in vivo

Fish & Shellfish Immunology, 2020
NLRP3 inflammasome is one of the most well-known inflammasomes in mammals, which plays critical roles in innate immunity. However, knowledge about this inflammasome in non-mammalian species, especially in teleost fish, remains rarely known. Herein, we established an Edwardsiella piscicida-head-kidney macrophages (HKMs) infection model in Japanese ...
Hao, Chen   +5 more
openaire   +2 more sources

Antitoxin HigA orchestrates T3SS/T6SS expression in aquatic pathogen Edwardsiella piscicida

Microbiological Research
Toxin-antitoxin (TA) systems are widely distributed in bacteria and archaea, playing crucial roles in multiple biological processes. As the type II TA system in Edwardsiella piscicida, HigB contributes to biofilm formation, intracellular propagation, and host infection.
Chunli, Li   +3 more
openaire   +2 more sources

The Role of UhpA in Regulating the Virulence Gene Expression in Edwardsiella piscicida

Journal of Fish Diseases, 2021
Cuimin Mu, Xuepeng Wang, Tingqi Ye
exaly  

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