Results 21 to 30 of about 537,505 (139)
Inhibition of Protein Synthesis by Didemnin B: How EF-1α Mediates Inhibition of Translocation†
, 2016 The antineoplastic cyclic depsipeptide didemnin B (DB) inhibits protein synthesis in cells and in vitro. The stage at which DB inhibits protein synthesis in cells is not known, although dehydrodidemnin B arrests translation at the stage of polypeptide ...
Bhagyashri V. SirDeshpande (2951778) +6 more
core +1 more source
Clonación y expresión recombinante del factor de elongación-1α de Leishmania infantum
, 2023 Introduction. In visceral leishmaniasis (VL), in old world caused by Leishmania donovani, elongation factor-1α (EF-1α) is an antigen-activator of SHP-1 phosphatase that inhibits the leishmanicidal activity of macrophages.
Castro García, Israel +5 more
core
BMEMat, EarlyView.Plant‐derived extracellular vesicles offer numerous advantages and are regarded as highly promising candidates in the field of biomedicine. Abstract Extracellular vesicles (EVs) are double‐membrane vesicular structures that can be secreted by nearly all living cells.
Zilin Li +6 more
wiley +1 more source
PGC-1α and Myokines in the aging muscle : a mini-review [PDF]
, 2011 Aging is associated with far-reaching changes in physiological functions resulting in morbidity and ultimately death. Age-related frailty, insecurity and reduced physical activity contribute to a progressive loss of muscle mass and function, commonly ...
Egger, A. +5 more
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Portal Hypertension &Cirrhosis, EarlyView.This perspective outlines China's contributions toward functional‐cure‐oriented antiviral therapies for chronic hepatitis B, summarizing key clinical data on bepirovirsen and domestic drug pipelines with balanced coverage of both promising and disappointing trial results.
Dandan Weng, Zhujun Cao, Qing Xie
wiley +1 more source
The efficiency of CMV or EF-1α promoter in hADMPCs.
, 2013 Lentiviral vectors encoding EGFP under the control of CMV or EF-1α promoter were transduced with hADMPCs at m.o.i. of 25, 50, 100, 250, 500, and 1000, and the cells were analyzed by flow cytometry.
Mariko Moriyama (420974) +6 more
core +1 more source
Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy
MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang +16 more
wiley +1 more source
Advanced Science, Volume 13, Issue 52, 18 September 2026.RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu +13 more
wiley +1 more source
, 2002 In order to develop a highly efficient mammalian expression vector, we constructed a vector by the combination of the murine cytomegalovirus (MCMV) immediate early (IE) promoter and the human elongation factor one alpha (EF-1α) first intron.
Yeon Soo Kim +4 more
core +1 more source
Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, Volume 42, Issue 5, September/October 2026.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source