Results 31 to 40 of about 537,505 (139)
Attenuation of DOX‐Associated Biochemical and Histological Brain Alterations
Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.This research highlights the need for practical methods to lessen the neurotoxicity caused by doxorubicin. ABSTRACT Background Doxorubicin (DOX) is a common anticancer drug used to treat various types of neoplasms. However, its use is associated with neurotoxic effects, including neuronal degeneration and damage.
Ehab Y. Abdelhiee +11 more
wiley +1 more source
Complex distribution of EFL and EF-1α proteins in the green algal lineage-3
, 2011 Copyright information:Taken from "Complex distribution of EFL and EF-1α proteins in the green algal lineage"http://www.biomedcentral.com/1471-2148/7/82BMC Evolutionary Biology 2007;7():82-82.Published online 23 May 2007PMCID:PMC1891102.
Geoffrey P Noble (75432) +2 more
core +1 more source
Effectiveness and safety of injectable human papilloma virus vaccine administered as eyedrops
, 2023 Mucosal vaccines have the advantages of ease of administration and the induction of strong mucosal immunity and a systemic immune response. Recently, the eye mucosa has been shown to be an effective and safe alternative vaccination route against ...
윤상철, 서경률, 이지혜
core +1 more source
Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter +20 more
wiley +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, Volume 59, Issue 9, September 2026.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
Monoclonal antibodies to elongation factor-1α inhibit in vitro translation in lysates of Sf21 cells
, 2003 Elongation factor-1α (EF-1α) is an enzyme that is essential for protein synthesis. Although EF-1α offers an excellent target for the disruption of insect metabolism, agents known to interfere with EF-1α activity are toxic to humans.
Chamberlain, N. R., Stuart, M. K.
core +1 more source
Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy
Advanced Materials, Volume 38, Issue 47, 21 August 2026.Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla +15 more
wiley +1 more source
MedComm, Volume 7, Issue 8, August 2026.Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong +8 more
wiley +1 more source
Cell Proliferation, Volume 59, Issue 8, August 2026.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
, 2014 A. Schematic of the proposed integration site of pEf-msa-1-Bm86ep-gfp-bsd into the ef-1α ORF of the B. bovis ef-1α locus. Large brackets with GenBank accession numbers KJ598132 and KJ598131 represent the regions amplified and sequenced to demonstrate ...
David A. Schneider (296568) +5 more
core +1 more source