Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis [PDF]
Article approval pendingEvidence of the risk of birth defects with efavirenz use is limited. We updated a meta-analysis of birth defects in infants with first trimester efavirenz exposure up to July 2011.
Alexandra Calmy +14 more
core +2 more sources
Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C [PDF]
Comunicación cortaWe assessed the relationship between atazanavir (ATV)-based antiretroviral treatment (ART) and plasma hepatitis C virus (HCV) viral load in a population of HIV/HCV-coinfected patients.
Girón-González, José-Antonio +5 more
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A Mutagenetic Tree Hidden Markov Model for Longitudinal Clonal HIV Sequence Data
RNA viruses provide prominent examples of measurably evolving populations. In HIV infection, the development of drug resistance is of particular interest, because precise predictions of the outcome of this evolutionary process are a prerequisite for the ...
Bacheler +14 more
core +2 more sources
The Doha Round’s Public Health Legacy: Strategies for the Production and Diffusion of Patented Medicines Under the Amended TRIPS Provisions [PDF]
This entry into force of the World Trade Organization (WTO) TRIPS Agreement in 1995 transformed the international intellectual property system. The harmonization of basic intellectual property standards has operated to protect investment in innovation ...
Abbott, Frederick M. +1 more
core +2 more sources
Antiretroviral treatment in HIV-1 infected pediatric patients: focus on efavirenz
Beatriz Larru,1 Jessica Eby,2,3 Elizabeth D Lowenthal2,4,51Department of Pediatrics, Division of Infectious Diseases, 2Department of Pediatrics, Division of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, 3Villanova University,
Larru B, Eby J, Lowenthal ED
doaj
Efavirenz is a reverse transcriptase non analog nucleoside inhibitor used to treat HIV infections. A simple assay method by high performance liquid chromatography was developed and validated for efavirenz tablets. The physical chemical characteristics of
Osnir de Sá Viana +9 more
doaj +1 more source
BackgroundImplication of pharmacogenetic variations and efavirenz pharmacokinetics in concomitant efavirenz based antiviral therapy and anti-tubercular drug induced liver injury (DILI) has not been yet studied.
Getnet Yimer +10 more
doaj +1 more source
Identifying Patterns in Health Care Disparities and Barriers to Health Care in Rural Tanzania [PDF]
Tanzania is a country in East Africa with a population of 55 million people. HIV/AIDs, malaria and nutritional deficiencies claim the lives of many each year across Tanzania.
Lull, Melinda E. +2 more
core +1 more source
Era of direct acting anti-viral agents for the treatment of hepatitis C. [PDF]
Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone.
Ahmed, Monjur
core +1 more source
The role of drug resistance in poor viral suppression in rural South Africa: findings from a population-based study. [PDF]
BACKGROUND:Understanding factors driving virological failure, including the contribution of HIV drug resistance mutations (DRM), is critical to ensuring HIV treatment remains effective.
Barnhart, Scott +9 more
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