Pharmaceutics, 2021 The noradrenaline and dopamine reuptake inhibitor bupropion is metabolized by CYP2B6 and recommended by the FDA as the only sensitive substrate for clinical CYP2B6 drug–drug interaction (DDI) studies.
Nina Hanke +2 more
exaly +3 more sources
Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells. [PDF]
Fundam Clin PharmacolABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Yu H, Lee SH, Kim JH, Kim SJ, Kang HE.
europepmc +2 more sources
Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations. [PDF]
Clin Pharmacol TherMajor depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Aguiar KEC +9 more
europepmc +2 more sources
Association of CYP2B6 and OPRM1 Genotypes with Methadone Dose Requirements and Serum Concentrations in a Vietnamese Cohorts [PDF]
Balkan Journal of Medical GeneticsTo characterize the prevalence of CYP2B6 and OPRM1 gene polymorphisms and evaluate their associations with serum methadone concentrations and dose requirements in Vietnamese patients undergoing methadone maintenance treatment (MMT).
Nguyen Quynh Giao +4 more
doaj +2 more sources
Pharmacokinetics, pharmacogenetics, and toxicity of co-administered efavirenz and isoniazid [PDF]
Southern African Journal of HIV MedicineBackground: CYP2B6 slow metabolisers have higher efavirenz concentrations, which are further increased by isoniazid inhibiting efavirenz’s accessory metabolic pathway.
Jessica Taylor +6 more
doaj +2 more sources
The Role of CYP2B6*6 Gene Polymorphisms in 3,5,6-Trichloro-2-pyridinol Levels as a Biomarker of Chlorpyrifos Toxicity Among Indonesian Farmers [PDF]
Journal of Preventive Medicine and Public Health, 2022 Objectives One of the most widely used pesticides today is chlorpyrifos (CPF). Cytochrome P450 (CYP)2B6, the most prominent catalyst in CPF bioactivation, is highly polymorphic.
Jen Fuk Liem +8 more
doaj +1 more source
CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function
Scientific Reports, 2022 Human CYP2B6 enzyme although constitutes relatively low proportion (1–4%) of hepatic cytochrome P450 content, it is the major catalyst of metabolism of several clinically important drugs (efavirenz, cyclophosphamide, bupropion, methadone).
Katalin Mangó +4 more
doaj +1 more source
Allelic and genotype frequencies of major CYP2B6 polymorphisms in the Pakistani population
Molecular Genetics & Genomic Medicine, 2021 Background Cytochrome P450 (CYP2B6) is an important enzyme that metabolizes about 3.0% of therapeutic drugs. Drugs metabolized mainly by CYP2B6 include artemisinin, bupropion, cyclophosphamide, efavirenz, ketamine, and methadone.
Sagheer Ahmed +4 more
doaj +1 more source
Frequencies of CYP2B6∗4,∗5, and ∗6 Alleles within an Iranian Population (Mazandaran)
Genetics Research, 2021 Background. The human CYP2B subfamily consists of one functional gene (CYP2B6) and one pseudogene (CYP2B7P). Cytochrome P450 2B6 (CYP2B6) is a highly polymorphic enzyme that shows marked interindividual and interethnic variations.
Mohammad Bagher Hashemi-Soteh +5 more
doaj +1 more source
Frequency of CYP2B6 Alleles in Major Iranian Ethnicities, Affecting Response to Efavirenz
Genetics Research, 2022 Introduction. Efavirenz is an antihuman immunodeficiency virus (HIV) drug metabolized by cytochrome P450 2B6 (CYP2B6) enzyme. Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. Polymorphisms of this gene play a crucial role in
Parham Mardi +4 more
doaj +1 more source