CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function [PDF]
Scientific Reports, 2022 Human CYP2B6 enzyme although constitutes relatively low proportion (1–4%) of hepatic cytochrome P450 content, it is the major catalyst of metabolism of several clinically important drugs (efavirenz, cyclophosphamide, bupropion, methadone).
Katalin Mangó +4 more
doaj +3 more sources
Efavirenz metabolism and CNS toxicity in Ugandan children: impact of CYP2B6 genotype and plasma metabolite profiles [PDF]
Frontiers in PharmacologyIntroductionThe non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) is used in antiretroviral therapy (ART) against HIV. EFV is mainly metabolized by CYP2B6 to 8-hydroxyefavirenz (8-OH-EFV) and to a lesser extent by CYP2A6 to 7 ...
Sandra Soeria-Atmadja +21 more
doaj +2 more sources
The Role of CYP2B6*6 Gene Polymorphisms in 3,5,6-Trichloro-2-pyridinol Levels as a Biomarker of Chlorpyrifos Toxicity Among Indonesian Farmers [PDF]
Journal of Preventive Medicine and Public Health, 2022 Objectives One of the most widely used pesticides today is chlorpyrifos (CPF). Cytochrome P450 (CYP)2B6, the most prominent catalyst in CPF bioactivation, is highly polymorphic.
Jen Fuk Liem +8 more
doaj +1 more source
Allelic and genotype frequencies of major CYP2B6 polymorphisms in the Pakistani population
Molecular Genetics & Genomic Medicine, 2021 Background Cytochrome P450 (CYP2B6) is an important enzyme that metabolizes about 3.0% of therapeutic drugs. Drugs metabolized mainly by CYP2B6 include artemisinin, bupropion, cyclophosphamide, efavirenz, ketamine, and methadone.
Sagheer Ahmed +4 more
doaj +1 more source
Frequencies of CYP2B6∗4,∗5, and ∗6 Alleles within an Iranian Population (Mazandaran)
Genetics Research, 2021 Background. The human CYP2B subfamily consists of one functional gene (CYP2B6) and one pseudogene (CYP2B7P). Cytochrome P450 2B6 (CYP2B6) is a highly polymorphic enzyme that shows marked interindividual and interethnic variations.
Mohammad Bagher Hashemi-Soteh +5 more
doaj +1 more source
Frequency of CYP2B6 Alleles in Major Iranian Ethnicities, Affecting Response to Efavirenz
Genetics Research, 2022 Introduction. Efavirenz is an antihuman immunodeficiency virus (HIV) drug metabolized by cytochrome P450 2B6 (CYP2B6) enzyme. Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. Polymorphisms of this gene play a crucial role in
Parham Mardi +4 more
doaj +1 more source
Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells. [PDF]
PLoS ONE, 2016 CYP2B6 plays an increasingly important role in xenobiotic metabolism and detoxification. The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) have been established as predominant regulators for the inductive expression of CYP2B6 ...
Linhao Li +3 more
doaj +1 more source
The Prevalence of Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia [PDF]
Osong Public Health and Research Perspectives, 2018 Objectives The CYP2B6 is one of the most polymorphic CYP genes in humans that has the potential to modify the pharmacological and toxicological responses to clinically important drugs such as antimalarial artemisinin and its derivatives.
Linawati Hananta +5 more
doaj +1 more source
CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes. [PDF]
PLoS ONE, 2013 The Cytochrome P450 2B6 (CYP2B6) enzyme makes a small contribution to hepatic nicotine metabolism relative to CYP2A6, but CYP2B6 is the primary enzyme responsible for metabolism of the smoking cessation drug bupropion.
A Joseph Bloom +5 more
doaj +1 more source
Platelets, 2020 Clopidogrel therapy reduces the occurrence of major vascular events in acute coronary syndrome (ACS) patients, but treatment efficacy is variable.
Wan-Lu Zhou +7 more
doaj +1 more source