Results 11 to 20 of about 16,133 (222)

Insights into CYP2B6-mediated drug–drug interactions

Acta Pharmaceutica Sinica B, 2016
Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed. The discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the ...
William D. Hedrich, Hazem E. Hassan, Hongbing Wang   +2 more
doaj   +3 more sources

PharmVar GeneFocus: CYP2B6 [PDF]

Clinical Pharmacology & Therapeutics, 2021
The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP2B6 gene. Genetic variation within the CYP2B6 gene locus impacts the metabolism or bioactivation of clinically important drugs. Of particular importance are efficacy and safety concerns regarding: efavirenz, which is used for the ...
Desta, Zeruesenay, El-Boraie, Ahmed, Gong, Li, Somogyi, Andrew A., Lauschke, Volker M., Dandara, Collet, Klein, Kathrin, Miller, Neil, Klein, Teri E., Tyndale, Rachel F., Whirl-Carrillo, Michelle, Gaedigk, Andrea   +11 more
openaire   +2 more sources

Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania. [PDF]

, 2012
To investigate the timing, incidence, clinical presentation, pharmacokinetics and pharmacogenetic predictors for antiretroviral and anti-tuberculosis drug induced liver injury (DILI) in HIV patients with or without TB co-infection.
A Habtewold, A Kwara, A Patel, A Tostmann, A Tostmann, A Tostmann, A Turkova, AK Daly, AM Anderson, B Lopman, BS Kappelhoff, C Benichou, C Nyakutira, CJ Hoffmann, CJ Hoffmann, D Voora, DF Wares, E Aklillu, E Aklillu, E Lopez-Lopez, E Ngaimisi, E Ngaimisi, E Pukenyte, Eleni Aklillu, Eliford Ngaimisi, Eric Sandstrom, Ferdinand Mugusi, G Yimer, G Yimer, G Yimer, GJ Dore, GL Dean, JG Stine, JJ Saukkonen, JK Mukonzo, JR Ungo, Juergen Burhenne, K Cohen, Klaus-Dieter Riedel, Lars Lindquist, LK Shipton, M Fiegenbaum, M Nelson, MI Matee, Mohamed Janabi, Muhammad Bakari, N Abrescia, N Soleman, Omary Minzi, P Kuehl, P Ocama, Petros C. Karakousis, R Kalyesubula, R Singla, RA Mirghani, S Russmann, Sabina Mugusi, SC Figueroa, SF Mugusi, V Gounden, W Mankhatitham, Z Desta, ZS Lamar   +62 more
core   +5 more sources

Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells. [PDF]

PLoS ONE, 2016
CYP2B6 plays an increasingly important role in xenobiotic metabolism and detoxification. The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) have been established as predominant regulators for the inductive expression of CYP2B6 ...
Linhao Li, Daochuan Li, Scott Heyward, Hongbing Wang   +3 more
doaj   +1 more source

The Prevalence of Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia [PDF]

Osong Public Health and Research Perspectives, 2018
Objectives The CYP2B6 is one of the most polymorphic CYP genes in humans that has the potential to modify the pharmacological and toxicological responses to clinically important drugs such as antimalarial artemisinin and its derivatives.
Linawati Hananta, Indwiani Astuti, Ahmad Hamim Sadewa, Josephine Alice, Jontari Hutagalung, Mustofa   +5 more
doaj   +1 more source

Molecular Characterization of CYP2B6 Substrates [PDF]

Current Drug Metabolism, 2008
CYP2B6 has not been as fully characterized at the molecular level as other members of the human cytochrome P450 family. As more widely used in vitro probes for characterizing the involvement of this enzyme in the metabolism of xenobiotics have become available, the number of molecules identified as CYP2B6 substrates has increased. In this study we have
Sean, Ekins, Manisha, Iyer, Matthew D, Krasowski, Evan D, Kharasch   +3 more
openaire   +2 more sources

CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes. [PDF]

PLoS ONE, 2013
The Cytochrome P450 2B6 (CYP2B6) enzyme makes a small contribution to hepatic nicotine metabolism relative to CYP2A6, but CYP2B6 is the primary enzyme responsible for metabolism of the smoking cessation drug bupropion.
A Joseph Bloom, Maribel Martinez, Li-Shiun Chen, Laura J Bierut, Sharon E Murphy, Alison Goate   +5 more
doaj   +1 more source

DEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells

Xenobiotica, 2021
The cytochrome P450 superfamily (CYPs) is a group of metabolic enzymes involved in drug biotransformation/metabolism. It is the most important drug metabolic enzyme; however, its mechanism of action remains unclear.We investigated the expression of CYP2B6 in HeLa cells induced by interleukin-6 (IL-6) and explored the relationship between differentially
Xiaofei, Luan, Yi, Zhao, Na, Bu, Yue, Chen, Nan, Chen   +4 more
openaire   +2 more sources

microRNA-605 rs2043556 polymorphisms affect clopidogrel therapy through modulation of CYP2B6 and P2RY12 in acute coronary syndrome patients

Platelets, 2020
Clopidogrel therapy reduces the occurrence of major vascular events in acute coronary syndrome (ACS) patients, but treatment efficacy is variable.
Wan-Lu Zhou, Zhen-Zhen Mo, Fei-Yan Xiao, Wei Dai, Guo Wang, Gan Zhou, Wei Zhang, Bi-Lian Chen   +7 more
doaj   +1 more source

Bioactivation of chlorpyrifos by CYP2B6 variants [PDF]

Xenobiotica, 2012
Chlorpyrifos (CPF), an organophosphorus (OP) pesticide, is bioactivated by cytochrome P450s (CYPs) to the active metabolite chlorpyrifos oxon (CPF-O). Given that human CYP2B6 has the highest intrinsic clearance (CL(int)) for CPF bioactivation, CYP2B6 polymorphisms may impact human susceptibility to CPF at real world environmental and occupational CPF ...
Alice L, Crane, Kathrin, Klein, James R, Olson   +2 more
openaire   +2 more sources