Results 31 to 40 of about 9,102 (179)

Vascularized Liver-on-a-Microsphere Reveals Alanine-Glucose Metabolism-Driven Regulation of Liver Function and Injury. [PDF]

Adv Sci (Weinh)
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Li J, Wu Z, Zhang Y, Chen S, Lin Y, Chen S, Xu T, Meng X, Zhang Y, Lin JM.   +9 more
europepmc   +2 more sources

The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans [PDF]

Drug Metabolism and Disposition, 2013
The effects of sex, ethnicity, and genetic polymorphism on hepatic CYP2B6 (cytochrome P450 2B6) expression and activity were previously demonstrated in vitro. Race/ethnic differences in CYP2B6 genotype and phenotype were observed only in women. To identify important covariates associated with interindividual variation in CYP2B6 activity in vivo, we ...
Katarina, Ilic, Roy L, Hawke, Ranjit K, Thirumaran, Erin G, Schuetz, J Heyward, Hull, Angela D M, Kashuba, Paul W, Stewart, Celeste M, Lindley, Mei-Ling, Chen   +8 more
openaire   +2 more sources

Influence of the CYP2B6 polymorphism on the pharmacokinetics of mitotane

Pharmacogenetics and Genomics, 2013
The aim of this study was to assess the potential impact of the pharmacogenetic variability of CYP2B6 and ABCB1 genes on the pharmacokinetics of mitotane.A retrospective analysis was carried out on 27 patients with adrenocortical carcinoma on postoperative adjunctive mitotane.
D'AVOLIO, ANTONIO, DE FRANCIA, SILVIA, BASILE, Vittoria, CUSATO, JESSICA, De Martino F, PIRRO, Elisa, Piccione F, Ardito A, Zaggia B, VOLANTE, Marco, DI PERRI, Giovanni, TERZOLO, Massimo   +11 more
openaire   +4 more sources

Synergistically Enhanced CYP2B6 Inducibility between a Polymorphic Mutation in CYP2B6 Promoter and Pregnane X Receptor Activation [PDF]

Molecular Pharmacology, 2010
CYP2B6 is a highly inducible and polymorphic enzyme involved in the metabolism of an increasing number of clinically important drugs. Significant interindividual variability in CYP2B6 expression has been attributed to either genetic polymorphisms or chemical-mediated induction through the activation of constitutive androstane receptor and/or pregnane X
Haishan, Li, Stephen S, Ferguson, Hongbing, Wang   +2 more
openaire   +2 more sources

The Cyp2b6 Gene Polymorphism and Phenotypic Correlation of Efavirenz-Based Combination Therapy Among the Niger Delta Ethnic Population: Implications in Modern Pharmacogenomics

Pharmacogenomics and Personalized Medicine, 2022
Samuel J Bunu, Azibanasamesa DC Owaba, Edebi N Vaikosen, Benjamin U Ebeshi Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, NigeriaCorrespondence: Samuel J Bunu Tel ...
Bunu JS, Azibanasamesa DC Owaba, Vaikosen EN, Ebeshi BU   +3 more
doaj  

Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

Clinical and Translational Science, 2022
Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants.
Line Skute Bråten, Magnus Ingelman‐Sundberg, Marin M. Jukic, Espen Molden, Marianne Kristiansen Kringen   +4 more
doaj   +1 more source

GABRA1 and GABRB2 Polymorphisms are Associated with Propofol Susceptibility

Pharmacogenomics and Personalized Medicine, 2022
Youjie Zeng,1 Si Cao,1 Minghua Chen,1 Chao Fang,1,2 Wen Ouyang1 1Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 2Hunan Cancer Hospital, The Affiliated Cancer Hospital ...
Zeng Y, Cao S, Chen M, Fang C, Ouyang W
doaj  

Pharmacogenetic-based efavirenz dose modification: suggestions for an African population and the different CYP2B6 genotypes. [PDF]

PLoS ONE, 2014
Pharmacogenetics contributes to inter-individual variability in pharmacokinetics (PK) of efavirenz (EFV), leading to variations in both efficacy and toxicity.
Jackson K Mukonzo, Joel S Owen, Jasper Ogwal-Okeng, Ronald B Kuteesa, Sarah Nanzigu, Nelson Sewankambo, Lehana Thabane, Lars L Gustafsson, Colin Ross, Eleni Aklillu   +9 more
doaj   +1 more source

Role of CYP2B6 in Stereoselective Human Methadone Metabolism [PDF]

Anesthesiology, 2008
Background Metabolism and clearance of racemic methadone are stereoselective and highly variable, yet the mechanism remains largely unknown. Initial in vitro studies attributed methadone metabolism to cytochrome P4503A4 (CYP3A4). CYP3A4 was also assumed responsible for methadone clearance in vivo.
Rheem A, Totah, Pamela, Sheffels, Toni, Roberts, Dale, Whittington, Kenneth, Thummel, Evan D, Kharasch   +5 more
openaire   +2 more sources

The Effects of Cumulative Dose and Polymorphisms in CYP2B6 on the Mitotane Plasma Trough Concentrations in Chinese Patients With Advanced Adrenocortical Carcinoma

Frontiers in Oncology, 2022
Mitotane is the only drug approved to treat adrenocortical carcinoma (ACC), and a relationship of pharmacokinetic/pharmacodynamic has been characterized.
Xin Liu, Xin Liu, Junmei Shang, Junmei Shang, Junmei Shang, Qiang Fu, Qiang Fu, Lin Lu, Lin Lu, Jianhua Deng, Jianhua Deng, Yan Tang, Yan Tang, Jiantao Li, Jiantao Li, Dan Mei, Dan Mei, Bo Zhang, Bo Zhang, Shuyang Zhang, Shuyang Zhang   +20 more
doaj   +1 more source