Results 51 to 60 of about 16,133 (222)

Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

Clinical and Translational Science, 2022
Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants.
Line Skute Bråten, Magnus Ingelman‐Sundberg, Marin M. Jukic, Espen Molden, Marianne Kristiansen Kringen   +4 more
doaj   +1 more source

GABRA1 and GABRB2 Polymorphisms are Associated with Propofol Susceptibility

Pharmacogenomics and Personalized Medicine, 2022
Youjie Zeng,1 Si Cao,1 Minghua Chen,1 Chao Fang,1,2 Wen Ouyang1 1Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 2Hunan Cancer Hospital, The Affiliated Cancer Hospital ...
Zeng Y, Cao S, Chen M, Fang C, Ouyang W
doaj  

The Cyp2b6 Gene Polymorphism and Phenotypic Correlation of Efavirenz-Based Combination Therapy Among the Niger Delta Ethnic Population: Implications in Modern Pharmacogenomics

Pharmacogenomics and Personalized Medicine, 2022
Samuel J Bunu, Azibanasamesa DC Owaba, Edebi N Vaikosen, Benjamin U Ebeshi Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, NigeriaCorrespondence: Samuel J Bunu Tel ...
Bunu JS, Azibanasamesa DC Owaba, Vaikosen EN, Ebeshi BU   +3 more
doaj  

Pharmacogenetic-based efavirenz dose modification: suggestions for an African population and the different CYP2B6 genotypes. [PDF]

PLoS ONE, 2014
Pharmacogenetics contributes to inter-individual variability in pharmacokinetics (PK) of efavirenz (EFV), leading to variations in both efficacy and toxicity.
Jackson K Mukonzo, Joel S Owen, Jasper Ogwal-Okeng, Ronald B Kuteesa, Sarah Nanzigu, Nelson Sewankambo, Lehana Thabane, Lars L Gustafsson, Colin Ross, Eleni Aklillu   +9 more
doaj   +1 more source

Implications of OPRM1 and CYP2B6 variants on treatment outcomes in methadone-maintained patients in Ontario: Exploring sex differences.

PLoS ONE, 2021
Genetic variants in the OPRM1 and CYP2B6 genes, respectively coding for an opioid receptor and methadone metabolizers, have been linked to negative treatment outcomes in patients undergoing methadone maintenance treatment, with little consensus on their ...
Caroul Chawar, Alannah Hillmer, Amel Lamri, Flavio Kapczinski, Lehana Thabane, Guillaume Pare, Zainab Samaan   +6 more
doaj   +1 more source

The Effects of Cumulative Dose and Polymorphisms in CYP2B6 on the Mitotane Plasma Trough Concentrations in Chinese Patients With Advanced Adrenocortical Carcinoma

Frontiers in Oncology, 2022
Mitotane is the only drug approved to treat adrenocortical carcinoma (ACC), and a relationship of pharmacokinetic/pharmacodynamic has been characterized.
Xin Liu, Xin Liu, Junmei Shang, Junmei Shang, Junmei Shang, Qiang Fu, Qiang Fu, Lin Lu, Lin Lu, Jianhua Deng, Jianhua Deng, Yan Tang, Yan Tang, Jiantao Li, Jiantao Li, Dan Mei, Dan Mei, Bo Zhang, Bo Zhang, Shuyang Zhang, Shuyang Zhang   +20 more
doaj   +1 more source

Pharmacogenetics of antiretroviral drugs [PDF]

, 2012
nem
Dragović Gordana, Grbović Leposava, Jevtović Đorđe   +2 more
core   +1 more source

Hepatocyte CYP2B6 Can Be Expressed in Cell Culture Systems by Exerting Physiological Levels of Shear: Implications for ADME Testing

Journal of Toxicology, 2017
Cytochrome 2B6 (CYP2B6) has substantial clinical effects on morbidity and mortality and its effects on drug metabolism should be part of hepatotoxicity screening.
Timothy G. Hammond, Holly H. Birdsall
doaj   +1 more source

Impact of Population and Pharmacogenetics Variations on Efavirenz Pharmacokinetics and Immunologic Outcomes During Anti-Tuberculosis Co-Therapy: A Parallel Prospective Cohort Study in Two Sub-Sahara African Populations

Frontiers in Pharmacology, 2020
Efavirenz-based combination antiretroviral-therapy (cART) is the recommended regimen during tuberculosis (TB) therapy. In a multi-national parallel prospective-cohort study, we investigated the impact of population and pharmacogenetic variations for ...
Sabina Mugusi, Sabina Mugusi, Abiy Habtewold, Eliford Ngaimisi, Wondwossen Amogne, Getnet Yimer, Omary Minzi, Eyasu Makonnen, Eyasu Makonnen, Christopher Sudfeld, Jürgen Burhenne, Eleni Aklillu   +11 more
doaj   +1 more source

METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6

Nutrition & Metabolism, 2023
Background Insulin resistance (IR) in hepatocytes endangers human health, and frequently results in the development of non-alcoholic fatty liver disease (NAFLD). Research on m6A methylation of RNA molecules has gained popularity in recent years; however,
Yongqing Li, Dantong Zhang, Yinan Gao, Peijun Wang, Zejun Wang, Bingyang Zhang, Junjun Liu, Diwen Ye, Wanshan Ma, Sumei Lu   +9 more
doaj   +1 more source