Results 61 to 70 of about 9,102 (179)

Association between CYP2B6 polymorphism and acute leukemia in a Han population of Northwest China

Molecular Genetics & Genomic Medicine, 2020
Background The aim of this study was to investigate potential associations between CYP2B6 c.516G>T polymorphism and the occurrence and prognosis of acute leukemias (AL) in the Han population of Northwest China.
Li‐Li Yu, Wei Zhang, Juan Li, Li Zhao
doaj   +1 more source

Integrating Pharmacogenomic Testing Within the 4Ms Framework for Management of Behavioral Symptoms in Advanced Vascular Dementia: A Case Study

Journal of the American Geriatrics Society, EarlyView.
Pharmacogenomic‐guided managment of behavioral symptoms within the 4Ms framework.
Gianna Franco, Collins Njoku, Mary L. Wagner, Fred A. Kobylarz   +3 more
wiley   +1 more source

The effects of CYP2B6 inactivators on the metabolism of ciprofol

PLOS ONE
Ciprofol is a novel short-acting intravenous anaesthetic developed in China that is mainly metabolized by cytochrome P450 2B6 (CYP2B6) and uridine diphosphate glucuronosyltransferase 1A9 (UGT1A9). Currently, insufficient evidence is available to support drug‒drug interactions between ciprofol and CYP2B6 inactivators.
Ming Lu, Xiaorui Zhang, Wenli Li, Xiangchen Li, Shan Li, Xiaoyu Yin, Zhiqing Zhang   +6 more
openaire   +3 more sources

CYP2B6 poor metaboliser alleles involved in efavirenz and nevirapine metabolism: CYP2B6*9 and CYP2B6*18 distribution in HIV-exposed subjects from Dschang, Western Cameroon

Infection, Genetics and Evolution, 2015
The prescription of patients' tailored anti-infectious treatments is the ultimate goal of pharmacogenetics/genomics applied to antimicrobial treatments, providing a basis for personalized medicine. Despite the efforts to screen Africans for alleles underlying defective metabolism for a panel of different drugs, still more research is necessary to ...
RUSSO, Gianluca, Sobze, Martin Sanou, Mayaka, George Bouting, Muthoga, Charles Waithaka, Tawe, Leabaneng, Martinelli, Axel, ROMANO, Rita, VULLO, Vincenzo, Paganotti, Giacomo Maria   +8 more
openaire   +3 more sources

Periodontal Infectogenomics in Africa: The Biological Case for a Population‐Centred Research Agenda

Journal of Periodontal Research, EarlyView.
African populations harbour the greatest human genetic diversity on earth and carry the highest global burden of severe periodontitis, yet their absence from periodontal infectogenomics represents a biological limitation of the field with profound implications for host‐microbe interaction research.
Salma Kabbashi, Manogari Chetty
wiley   +1 more source

Efavirenz Intoxication Due to a New Cyp2B6 Constellation

Antiviral Therapy, 2013
Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein.
Anagnostopoulos, Alexia, Rotger, Margalida, Aouri, Manel, Kuster, Stefan P, Telenti, Amalio, Décosterd, Laurent A, Günthard, Huldrych F   +6 more
openaire   +4 more sources

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Association of CYP2B6 and OPRM1 Genotypes with Methadone Dose Requirements and Serum Concentrations in a Vietnamese Cohorts

Balkan Journal of Medical Genetics
To characterize the prevalence of CYP2B6 and OPRM1 gene polymorphisms and evaluate their associations with serum methadone concentrations and dose requirements in Vietnamese patients undergoing methadone maintenance treatment (MMT).
Nguyen Quynh Giao, Tran Khanh Chi, Trinh Thi Phuong Dung, Pham Huy Tan, Dang Thi Ngoc Dung   +4 more
doaj   +1 more source

Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity

Scientific Reports, 2022
Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear receptors. CAR and PXR are encoded by genetically polymorphic NR1I2 and NR1I3, respectively.
Zelalem Petros, Abiy Habtewold, Eyasu Makonnen, Eleni Aklillu   +3 more
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source