Results 81 to 90 of about 9,102 (179)

Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults

AIDS Research and Therapy, 2010
Background Cytochrome P450 2B6 (CYP2B6) metabolizes efavirenz and nevirapine, the major core antiretroviral drugs for HIV in Thailand. Rifampicin, a critical component of tuberculosis (TB) therapy is a potent inducer of CYP enzyme activity. Polymorphisms
Kalambaheti Thareerat, Wichukchinda Nuanjun, Manosuthi Weerawat, Likanonsakul Sirirat, Uttayamakul Sumonmal, Nakayama Emi E, Shioda Tatsuo, Khusmith Srisin   +7 more
doaj   +1 more source

Clinical and genetic determinants of nevirapine plasma trough concentration

SAGE Open Medicine, 2018
Background: Only few data are available on the influence of CYP2B6 and CYP3A4/A5 polymorphisms on nevirapine plasma concentrations in the Caucasian population.
Andrea Giacomelli, Stefano Rusconi, Felicia Stefania Falvella, Maria Letizia Oreni, Dario Cattaneo, Valeria Cozzi, Giulia Renisi, Elisa Monge, Stefania Cheli, Emilio Clementi, Agostino Riva, Massimo Galli, Anna Lisa Ridolfo   +12 more
doaj   +1 more source

CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

Clinical and Translational Science, 2019
We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe.
Ingrid F. Metzger, Nimita Dave, Yvonne Kreutz, Jessica B.L. Lu, Raymond E. Galinsky, Zeruesenay Desta   +5 more
doaj   +1 more source

CYP2B6*6 or Not CYP2B6*6—That Remains a Question for Precision Medicine and Ketamine! [PDF]

Anesthesiology, 2016
Scott D, Cook-Sather, Peter C, Adamson, Jin, Li, Hakon, Hakonarson   +3 more
openaire   +2 more sources

A pharmacogenomic prospective randomized controlled trial of CYP2B6 polymorphisms and efavirenz dose adjustment among HIV-infected Thai patients: a pilot study

Pharmacogenomics and Personalized Medicine, 2015
Pansachee Damronglerd,1 Chonlaphat Sukasem,2,4 Wilawan Thipmontree,3 Apichaya Puangpetch,2,4 Sasisopin Kiertiburanakul1 1Deparment of Medicine, 2Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 3Department ...
Damronglerd P, Sukasem C, Thipmontree W, Puangpetch A, Kiertiburanakul S   +4 more
doaj  

Genetic variants, haplotype determination, and function of novel alleles of CYP2B6 in a Han Chinese population

Heliyon
Amino acid variants in protein may result in deleterious effects on enzymatic activity. In this study we investigate the DNA variants on activity of CYP2B6 gene in a Chinese Han population for potential use in precision medicine. All exons in CYP2B6 gene
Li-Qun Zhang, Xin-Yue Li, Lian-Guo Chen, Zhe Chen, Ren-Ai Xu, Jian-Chang Qian, Xiao-yang Zhou, Da-Peng Dai, Guo-Xin Hu, Jian-Ping Cai   +9 more
doaj   +1 more source

Pharmacokinetic variability of mitotane in pediatric adrenocortical carcinoma and the role of CYP2B6 genotypes: a pediatric case series

EJC Paediatric Oncology
Despite therapeutic drug monitoring of mitotane, achieving target plasma concentrations remains challenging. Commonly reported enzymes involved in mitotane metabolism are cytochrome P450 (CYP)3A4 and 2B6, with CYP2B6 being highly polymorphic.
Ivy A.E. Ankone, Tirsa de Kluis, Lidwien M. Hanff, Antoinette Jaspers-Bakker, Ronald R. de Krijger, Jesse J. Swen, Kathalijne A. Oudhoff, Marieke J.M. Meijs, Max M. van Noesel, Alwin D.R. Huitema, Meta H.M. Diekstra   +10 more
doaj   +1 more source

CYP2B6 Gene [PDF]

, 2020
openaire   +1 more source

Association between the CYP2B6 polymorphisms and nonnucleoside reverse transcriptase inhibitors drug-induced liver injury: a systematic review and meta-analysis

Scientific Reports
Nevirapine (NVP) and Efavirenz (EFV) can cause antiretroviral drug-induced liver injury (ARVDILI). The objectives of this study were to summarize and analyze existing data on pharmacogenomics associated with nonnucleoside reverse transcriptase inhibitors
Noppadol Chanhom, Janjira Sonjan, Jarupat Inchai, Wanvisa Udomsinprasert, Usa Chaikledkaew, Supharat Suvichapanich, Surakameth Mahasirimongkol, Jiraphun Jittikoon   +7 more
doaj   +1 more source

CYP2B6

Journal of Postgraduate Medicine, 2012
openaire   +2 more sources