Results 101 to 110 of about 16,133 (222)

The Burden of Adverse Drug Reactions in Africa in the Context of Pharmacogenetics‐Based Clinical Guidelines

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.
Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield, Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Collen Masimirembwa   +5 more
wiley   +1 more source

The Impact of Genotoxicity in Coke Oven Workers: Systematic Review With Meta‐Analysis

Journal of Applied Toxicology, Volume 46, Issue 5, Page 1460-1475, May 2026.
ABSTRACT This systematic review (SR) with meta‐analysis investigates the genotoxicity potential of coke oven workers (COWs) exposed to polycyclic aromatic hydrocarbons (PAHs) through a comprehensive analysis of studies retrieved from PubMed, SCOPUS, and Web of Science.
Thiago Guedes Pinto, Vinícius Fialho do Nascimento, Giovanna Abreu Holanda Guerra, Wilton Mitsunari Takeshita, Raquel Alves Sales, Andrea Cristina de Moraes Malinverni, Luciana Lopes Guimaraes, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Efavirenz metabolism and CNS toxicity in Ugandan children: impact of CYP2B6 genotype and plasma metabolite profiles

Frontiers in Pharmacology
IntroductionThe non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) is used in antiretroviral therapy (ART) against HIV. EFV is mainly metabolized by CYP2B6 to 8-hydroxyefavirenz (8-OH-EFV) and to a lesser extent by CYP2A6 to 7 ...
Sandra Soeria-Atmadja, Sandra Soeria-Atmadja, Madeleine Pettersson Bergstrand, Madeleine Pettersson Bergstrand, Pauline Amuge, Pauline Amuge, Sarah Nanzigu, Dickson Bbuye, Johanna Rubin, Johanna Rubin, Adeodata Kekitiinwa, Celestino Obua, Marja-Liisa Dahl, Marja-Liisa Dahl, Anton Pohanka, Anton Pohanka, Lars L. Gustafsson, Lars Navér, Lars Navér, Jaran Eriksen, Jaran Eriksen, Jaran Eriksen   +21 more
doaj   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug‐Metabolizing Enzymes

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time‐dependent inhibitor of
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Steven Good, Arantxa Horga, Nancy Agrawal, Janet Hammond   +10 more
wiley   +1 more source

The Influence of CYP2B6 Variants and Administration of Propofol on Patient Outcomes after Traumatic Brain Injury

Neurotrauma Reports
Management of severe traumatic brain injury (sTBI) typically involves the use of sedation, which inherently results in benefits and risks. The cytochrome P450 enzyme CYP2B6 is involved in the biotransformation of particular drug classes, including many ...
Katherine O’Meara, Ava M. Puccio, Dianxu Ren, Sandra Deslouches, Ruchira Jha, David O. Okonkwo, Yvette P. Conley   +6 more
doaj   +1 more source

Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers. [PDF]

, 2017
Background Neonatal abstinence syndrome (NAS) in infants of methadone-maintained opioid-dependent (MMOD) mothers cannot be predicted in individual cases. We investigated whether variation in infant genotype is associated with severity of NAS.
Gillis, C., Mactier, H., McLaughlin, Poppy, Osselton, David M.   +3 more
core   +1 more source

Population Pharmacokinetics and Dosing Simulations of Pentobarbital in the Pediatric Population

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Pentobarbital is a barbiturate with sedative and anticonvulsant properties, occasionally used in pediatric patients for preoperative sedation, deep sedation during mechanical ventilation, and seizure control. Despite its long‐standing clinical use, age‐appropriate dosing remains challenging due to variability across studies and limited ...
Victoria Etges Helfer, Lorena Medina‐Aymerich, William J. Muller, Marisa Meyer, Amira Al‐Uzri, Russell McCulloh, Chi D. Hornik, Stephen J. Balevic, Rachel G. Greenberg, Daniel K. Benjamin Jr., Sarah G. Anderson, Daniel Gonzalez, the Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee   +12 more
wiley   +1 more source

Efavirenz Intoxication Due to Slow Hepatic Metabolism [PDF]

, 2017
We describe a human immunodeficiency virus-positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high.
Bleiber, G., Günthard, H. F., Hasse, B., Krause, M.   +3 more
core  

Effects of monocyte chemoattractant protein‐1, macrophage inflammatory protein‐1α, and interferon‐α2a on P450 enzymes in human hepatocytes in vitro

Pharmacology Research & Perspectives, 2019
Some immunomodulatory agents stimulate the release of cytokines capable of suppressing P450 enzymes and potentially affecting pharmacokinetics of coadministered medications. Cytokines released in response to an immunomodulator in the blood ex vivo can be
Maciej Czerwiński, Krystal Gilligan, Kevin Westland, Brian W. Ogilvie   +3 more
doaj   +1 more source

Validation of computational approaches for antiretroviral dose optimization [PDF]

, 2016
Strategies for reducing antiretroviral doses and drug costs can support global access, and numerous options are being investigated. Efavirenz pharmacokinetic simulation data generated with a bottom-up physiologically based model were successfully ...
Dickinson, L, Owen, A, Siccardi, M
core   +1 more source