Results 121 to 130 of about 9,102 (179)

Correction: The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals. [PDF]

Arch Toxicol
Henderson CJ, McLaren AW, MacLeod AK, Lin D, Cameron AR, Chatham LR, Moggs J, Inesta-Vaquera F, Thomson JP, Meehan RR, Chakravarty P, Schwarz M, Roland Wolf C.   +12 more
europepmc   +1 more source

Pharmacogenomic-Guided Prescribing for Treatment-Resistant Mental Health Conditions in Australian Primary Care: A Single-GP Practice Retrospective Observation of 29 Patients. [PDF]

Int J Mol Sci
Beer C, Rae F, Watt M, Semmler A, Voisey J.   +4 more
europepmc   +1 more source

Evaluation of the cytochrome P450-mediated drug interaction profile of olorofim. [PDF]

Antimicrob Agents Chemother
Cornelissen K, Rex JH, Zinzi D, Law D, Upcott Gill R, Jones HM, Maertens J, Chen SC-A, Brüggemann R.   +8 more
europepmc   +1 more source

Fenfluramine for seizures in Dravet syndrome and Lennox-Gastaut syndrome: Mechanisms, clinical evidence, safety, and practical integration. [PDF]

Epilepsy Behav Rep
Janszky J, Janszky J, Horváth R.
europepmc   +1 more source

Benchmark of Open-Access Star-Allele Callers to Accurately Assess Haplotypes and Phenotypes in Pharmacogenetic Studies. [PDF]

Clin Pharmacol Ther
Gros-La-Faige MB, Génin E, Herzig AF.
europepmc   +1 more source

Genotipizacija CYP2B6 u kliničkoj praksi

Major depressive disorder represents a significant public health problem, and selective serotonin reuptake inhibitors (SSRIs), such as sertraline, are commonly used in its treatment. However, due to genetic differences among individuals, variability in drug metabolism may occur, which can affect treatment efficacy and the occurrence of adverse effects.
openaire   +1 more source

Factors Influencing Phenoconversion in CYP-Mediated Drug Metabolism: A Scoping Review. [PDF]

Pharmacy (Basel)
Scodellaro S, Triantafilou S, Cohn I.
europepmc   +1 more source

Contribution of cytochrome P450-mediated metabolism to clavulanic acid-induced cytotoxicity in TK6-derived cytochrome P450-overexpressing cell lines. [PDF]

Sci Rep
Fang JL, Li X, Chen S, Beland FA.
europepmc   +1 more source

Impact of Efavirenz on Heme Protein Induction and Biomarkers: Insights From In Vitro Experiments and a Clinical Study. [PDF]

Clin Transl Sci
Potzel L, Kinzi J, Seibert I, Grube M, Siegmund W, Meyer Zu Schwabedissen HE.   +5 more
europepmc   +1 more source

Genetic Variation in <i>CYP2B6</i>, <i>UGT1A4</i> and Sulfotransferases Is Associated with Disease-Free Survival in South African Breast Cancer Patients Treated with Tamoxifen. [PDF]

J Pers Med
Kruger B, Chimusa ER, Abera AB, Singh J, Shamley D, Dandara C.   +5 more
europepmc   +1 more source