Results 121 to 130 of about 16,133 (222)

Pharmacokinetic variability of mitotane in pediatric adrenocortical carcinoma and the role of CYP2B6 genotypes: a pediatric case series

EJC Paediatric Oncology
Despite therapeutic drug monitoring of mitotane, achieving target plasma concentrations remains challenging. Commonly reported enzymes involved in mitotane metabolism are cytochrome P450 (CYP)3A4 and 2B6, with CYP2B6 being highly polymorphic.
Ivy A.E. Ankone, Tirsa de Kluis, Lidwien M. Hanff, Antoinette Jaspers-Bakker, Ronald R. de Krijger, Jesse J. Swen, Kathalijne A. Oudhoff, Marieke J.M. Meijs, Max M. van Noesel, Alwin D.R. Huitema, Meta H.M. Diekstra   +10 more
doaj   +1 more source

CYP2B6*6 or Not CYP2B6*6—That Remains a Question for Precision Medicine and Ketamine! [PDF]

Anesthesiology, 2016
Scott D, Cook-Sather, Peter C, Adamson, Jin, Li, Hakon, Hakonarson   +3 more
openaire   +2 more sources

Pharmacokinetic interactions of pioglitazone [PDF]

, 2007
Pioglitazone is a thiazolidinedione compound used in the treatment of type 2 diabetes. It has been reported to be metabolised by multiple cytochrome P450 (CYP) enzymes, including CYP2C8, CYP2C9 and CYP3A4 in vitro.
Jaakkola, Tiina
core  

CYP2B6 Gene [PDF]

, 2020
openaire   +1 more source

Association between the CYP2B6 polymorphisms and nonnucleoside reverse transcriptase inhibitors drug-induced liver injury: a systematic review and meta-analysis

Scientific Reports
Nevirapine (NVP) and Efavirenz (EFV) can cause antiretroviral drug-induced liver injury (ARVDILI). The objectives of this study were to summarize and analyze existing data on pharmacogenomics associated with nonnucleoside reverse transcriptase inhibitors
Noppadol Chanhom, Janjira Sonjan, Jarupat Inchai, Wanvisa Udomsinprasert, Usa Chaikledkaew, Supharat Suvichapanich, Surakameth Mahasirimongkol, Jiraphun Jittikoon   +7 more
doaj   +1 more source

CYP2B6 wt Allele [PDF]

, 2020
openaire   +1 more source

PharmGKB summary: very important pharmacogene information for CYP2B6 [PDF]

Pharmacogenetics and Genomics, 2010
Caroline F, Thorn, Jatinder K, Lamba, Vishal, Lamba, Teri E, Klein, Russ B, Altman   +4 more
openaire   +2 more sources

Pharmakogenetik in der Rechtsmedizin [PDF]

, 2018
Zusammenfassung: Die Pharmakogenetik beschäftigt sich mit den genetisch bedingten Unterschieden bei der Arzneimittel-, Drogen oder Giftwirkung und ist somit auch für die rechtsmedizinische Begutachtung von Bedeutung.
Krämer, T.
core  

CYP2B6

Journal of Postgraduate Medicine, 2012
openaire   +2 more sources

New cathinone-derived designer drugs 3-bromomethcathinone and 3-fluoromethcathinone : studies on their metabolism in rat urine and human liver microsomes using GC-MS and LC-high-resolution MS and their detectability in urine [PDF]

, 2012
Vollmar, Christian
core   +1 more source