Results 141 to 150 of about 9,102 (179)

Role of Polymorphic Human CYP2B6 in Cyclophosphamide Bioactivation [PDF]

Pharmacogenomics Journal, 2003
The role of polymorphic CYP2B6 in cyclophosphamide (CPA) bioactivation was investigated in human liver microsomes. A total of 67 human liver specimens were first genotyped with respect to the CYP2B6*5 and CYP2B6*6 variant alleles. CYP2B6 apoprotein levels in 55 liver microsomal preparations were assessed by immunoblotting.
Ümit Yaşar, Anders Rane, Moustapha Hassan   +2 more
exaly   +3 more sources

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Human CYP2B6

Pharmacogenetics, 1999
Human cytochrome (CYP)2B6 cDNA was cloned and expressed in bacteria and in yeast. Its expression in Saccharomyces cerevisiae enabled us to obtain, at a high level, an active yeast-expressed CYP2B6 protein, so as to assess its role in the metabolism of ethoxyresorufin, pentoxyresorufin, benzyloxyresorufin, ethoxycoumarin, testosterone and ...
L, Gervot, B, Rochat, J C, Gautier, F, Bohnenstengel, H, Kroemer, V, de Berardinis, H, Martin, P, Beaune, I, de Waziers   +8 more
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Oxypeucedanin is a Mechanism-based Inactivator of CYP2B6 and CYP2D6

Current Drug Metabolism, 2021
Background: Herbal medicine Angelica dahurica is widely employed for the treatment of rheumatism and pain relief in China. Oxypeucedanin is a major component in the herb. Objectives : The objectives of this study are aimed at the investigation of mechanism-based inactivation of CYP2B6 and CYP2D6 by oxypeucedanin, characterization of the reactive ...
Kehan Zhang, Yilin Li, Yao Fu, Tiantian Cui, Qian Wang, Xu Mao, Ying Peng, Jiang Zheng   +7 more
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Involvement of CYP2D6 and CYP2B6 on Tramadol Pharmacokinetics

Pharmacogenomics, 2020
This study included 24 healthy volunteers who received a single 37.5 mg oral dose of tramadol. We analyzed 18 polymorphisms within CYP2D6, CYP2B6, CYP3A, COMT, ABCB1, SLC22A1 and OPRM1 genes by quantitative PCR, to study whether these polymorphisms affect its pharmacokinetics, pharmacodynamics and safety. CYP2D6 intermediate metabolizers (n = 6) showed
Miriam Saiz-Rodríguez, Dolores Ochoa, Manuel Román, Pablo Zubiaur, Dora Koller, Gina Mejía, Francisco Abad-Santos   +6 more
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Stereoselectivity in metabolism of ifosfamide by CYP3A4 and CYP2B6

Xenobiotica, 2006
The aim was to identify the hepatic cytochromes P450 (CYPs) responsible for the enantioselective metabolism of ifosfamide (IFA). The 4-hydroxylation, N2- and N3-dechloroethylation of IFA enantiomers were monitored simultaneously in the same metabolic systems using GC/MS and pseudoracemate techniques.
H, Lu, J J, Wang, K K, Chan, P A, Philip
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Identification of miRNAs that regulate human CYP2B6 expression

Drug Metabolism and Pharmacokinetics, 2021
Human hepatic cytochrome P450 2B6 (CYP2B6) expressed is responsible for the metabolism of many drugs, such as cyclophosphamide, ifosfamid, and efavirenz. In the present study, the correlation between CYP2B6 mRNA and protein levels in human liver samples was found to be moderate, indicating a contribution of posttranscriptional regulation of CYP2B6 ...
Masataka, Nakano, Chika, Iwakami, Tatsuki, Fukami, Miki, Nakajima   +3 more
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Examination of purported probes of human CYP2B6

Pharmacogenetics, 1997
7-Ethoxy-4-trifluoromethylcoumarin (7-EFC) was examined as a substrate for cytochrome P450 (P450) in microsomes from human livers and expressed in B-lymphoblastoid cells. The O-deethylation of 7-EFC to 7-hydroxy-4-trifluoromethylcoumarin (7-HFC) varied over a liver bank (n = 19) by a factor of 13 (40-507 pmol min-1 mg-1 protein). When compared with the
S, Ekins, M, VandenBranden, B J, Ring, S A, Wrighton   +3 more
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THE ROLE OF CYP2B6 IN HUMAN XENOBIOTIC METABOLISM*

Drug Metabolism Reviews, 1999
The cytochromes P450 (CYP) comprise a large multigene family of heme-thiolate proteins which are of considerable importance in the metabolism of xenobiotics and endobiotics.
S, Ekins, S A, Wrighton
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Artemisinin–a possible CYP2B6 probe substrate?

Biopharmaceutics & Drug Disposition, 2009
AbstractAim. To comparein vitrometabolism rates for artemisinin and the CYP2B6 substrates, bupropion, propofol and efavirenz in human liver microsomes.Methods. Rate constants of artemisinin, bupropion, propofol and efavirenz metabolism by human liver microsomes from a panel of 12 donors, with different levels of CYP2B6 activity, were estimated in ...
Sara, Asimus, Michael, Ashton
openaire   +2 more sources