Results 111 to 120 of about 16,133 (222)

Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity

PLoS ONE, 2022
Multiple factors in addition to over consumption lead to obesity and non-alcoholic fatty liver disease (NAFLD) in the United States and worldwide. CYP2B6 is the only human detoxification CYP whose loss is associated with obesity, and Cyp2b-null mice show
Melissa M. Heintz, Jazmine A. Eccles, Emily M. Olack, Kristal M. Maner-Smith, Eric A. Ortlund, William S. Baldwin   +5 more
doaj  

A network biology-based approach to evaluating the effect of environmental contaminants on human interactome and diseases

, 2018
Environmental contaminant exposure can pose significant risks to human health. Therefore, evaluating the impact of this exposure is of great importance; however, it is often difficult because both the molecular mechanism of disease and the mode of action
Iida, Midori, Takemoto, Kazuhiro
core   +1 more source

Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults

AIDS Research and Therapy, 2010
Background Cytochrome P450 2B6 (CYP2B6) metabolizes efavirenz and nevirapine, the major core antiretroviral drugs for HIV in Thailand. Rifampicin, a critical component of tuberculosis (TB) therapy is a potent inducer of CYP enzyme activity. Polymorphisms
Kalambaheti Thareerat, Wichukchinda Nuanjun, Manosuthi Weerawat, Likanonsakul Sirirat, Uttayamakul Sumonmal, Nakayama Emi E, Shioda Tatsuo, Khusmith Srisin   +7 more
doaj   +1 more source

Single Dose Pharmacokinetics of Efavirenzin Healthy Indian Subjects [PDF]

, 2007
Background & Objective: Access to antiretroviral therapy in India is improving. Efavirenz (EFV) is a commonly used non-nucleoside reverse transcriptase inhibitor used to treat HIV infection. No information is available on the pharmacokinetics of EFV in
Hemanth Kumar, A K, Kumaraswami, V, Ramachandran, Geetha, Sukumar, B, Swaminathan, Soumya   +4 more
core  

Clinical and genetic determinants of nevirapine plasma trough concentration

SAGE Open Medicine, 2018
Background: Only few data are available on the influence of CYP2B6 and CYP3A4/A5 polymorphisms on nevirapine plasma concentrations in the Caucasian population.
Andrea Giacomelli, Stefano Rusconi, Felicia Stefania Falvella, Maria Letizia Oreni, Dario Cattaneo, Valeria Cozzi, Giulia Renisi, Elisa Monge, Stefania Cheli, Emilio Clementi, Agostino Riva, Massimo Galli, Anna Lisa Ridolfo   +12 more
doaj   +1 more source

CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

Clinical and Translational Science, 2019
We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe.
Ingrid F. Metzger, Nimita Dave, Yvonne Kreutz, Jessica B.L. Lu, Raymond E. Galinsky, Zeruesenay Desta   +5 more
doaj   +1 more source

A pharmacogenomic prospective randomized controlled trial of CYP2B6 polymorphisms and efavirenz dose adjustment among HIV-infected Thai patients: a pilot study

Pharmacogenomics and Personalized Medicine, 2015
Pansachee Damronglerd,1 Chonlaphat Sukasem,2,4 Wilawan Thipmontree,3 Apichaya Puangpetch,2,4 Sasisopin Kiertiburanakul1 1Deparment of Medicine, 2Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 3Department ...
Damronglerd P, Sukasem C, Thipmontree W, Puangpetch A, Kiertiburanakul S   +4 more
doaj  

Genetic variants, haplotype determination, and function of novel alleles of CYP2B6 in a Han Chinese population

Heliyon
Amino acid variants in protein may result in deleterious effects on enzymatic activity. In this study we investigate the DNA variants on activity of CYP2B6 gene in a Chinese Han population for potential use in precision medicine. All exons in CYP2B6 gene
Li-Qun Zhang, Xin-Yue Li, Lian-Guo Chen, Zhe Chen, Ren-Ai Xu, Jian-Chang Qian, Xiao-yang Zhou, Da-Peng Dai, Guo-Xin Hu, Jian-Ping Cai   +9 more
doaj   +1 more source

Personalized prescribing: a new medical model for clinical implementation of psychotropic drugs. [PDF]

, 2016
The use of pharmacogenetic tests was already being proposed in psychiatry in the early 2000s because genetic factors were known to influence drug pharmacokinetics and pharmacodynamics.
Eap, C.B.
core   +1 more source

Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes [PDF]

, 2019
Bloom, Adam Joseph, Kharasch, Evan D, Wang, Pan-Fen   +2 more
core   +2 more sources