Results 21 to 30 of about 16,133 (222)
Dataset of endo- and xenobiotic inhibition of CYP2B6: Comparison to CYP3A4
Data in Brief, 2022 Cytochrome P450 2B6 (CYP2B6) is a human enzyme important in chemical detoxification, steroid and fatty acid metabolism that is primarily hepatic. Therefore, induction or inhibition of CYP2B6 may perturb endo- and xenobiotic metabolism and cause adverse ...
Emily M. Olack +2 more
doaj +1 more source
Synergistically Enhanced CYP2B6 Inducibility between a Polymorphic Mutation in CYP2B6 Promoter and Pregnane X Receptor Activation [PDF]
Molecular Pharmacology, 2010 CYP2B6 is a highly inducible and polymorphic enzyme involved in the metabolism of an increasing number of clinically important drugs. Significant interindividual variability in CYP2B6 expression has been attributed to either genetic polymorphisms or chemical-mediated induction through the activation of constitutive androstane receptor and/or pregnane X
Haishan, Li +2 more
openaire +2 more sources
Genetics Research, 2023 Background. Cytochrome P450 complex plays a key role in drug metabolism. CYP2B6 has an essential part in Cytochrome P450 complex metabolism. This study aims to determine the allelic distribution of CYP2B6∗2 and CYP2B6∗3 in three main Iranian ethnicities:
Armin Khavandegar +7 more
doaj +1 more source
Frontiers in Genetics, 2021 Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality worldwide. It is well-known that individual genetic make-up is one of the causative factors of ADRs.
Immaculate M. Langmia +5 more
doaj +1 more source
Medicine, 2022 . The two non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP), are currently the core antiretroviral drugs for treatment of HIV in sub-Saharan Africa including Botswana.
Monkgomotsi J. Maseng, BSc +10 more
doaj +1 more source
EXPRESSION OF PXR, MDR1, CYP3A5, AND CYP2B6 IN HIGH-GRADE SEROUS OVARIAN CANCER AND ITS SIGNIFICANCE [PDF]
精准医学杂志, 2023 Objective To investigate the expression and significance of progesterone X receptor (PXR), multidrug resistant protein 1 (MDR1), cytochrome P450 3A5 (CYP3A5), and cytochrome P450 2B6 (CYP2B6) in high-grade serous ovarian cancer (HGSOC).
ZHANG Ping, MA Lan, CHEN Hua
doaj +1 more source
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]
, 2014 To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel +10 more
core +1 more source
Differences in Methadone Metabolism by CYP2B6 Variants [PDF]
Drug Metabolism and Disposition, 2015 Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N-demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP).
Sarah, Gadel +2 more
openaire +2 more sources
The utility of efavirenz-based prophylaxis against HIV infection. A systems pharmacological analysis [PDF]
, 2019 Pre-exposure prophylaxis (PrEP) is considered one of the five “pillars” by UNAIDS to reduce HIV transmission. Moreover, it is a tool for female self-protection against HIV, making it highly relevant to sub-Saharan regions, where women have the highest ...
Dickinson, Laura +4 more
core +4 more sources
Distribution of CYP2B6 516G/T pharmacogenetically important polymorphism in the Ukrainian population
Saudi Pharmaceutical Journal, 2018 The CYP2B6 is one of the members of the cytochrome P450 superfamily. This enzyme metabolizes a number of currently prescribed drugs and different compounds.
Olga Filiptsova +6 more
doaj +1 more source