Results 21 to 30 of about 9,102 (179)

CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations—Implication for Drug Safety, Dosing, and Individualized Therapy

Frontiers in Genetics, 2021
Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality worldwide. It is well-known that individual genetic make-up is one of the causative factors of ADRs.
Immaculate M. Langmia, Katja S. Just, Sabrina Yamoune, Jürgen Brockmöller, Collen Masimirembwa, Julia C. Stingl   +5 more
doaj   +1 more source

The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes

Medicine, 2022
. The two non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP), are currently the core antiretroviral drugs for treatment of HIV in sub-Saharan Africa including Botswana.
Monkgomotsi J. Maseng, BSc, Leabaneng Tawe, PhD, Prisca K. Thami, PhD, Sikhulile Moyo, PhD, Ishmael Kasvosve, PhD, Vladimir Novitsky, PhD, Max Essex, PhD, Gianluca Russo, PhD, Simani Gaseitsiwe, PhD, Giacomo M. Paganotti, PhD, Jorddy Neves Cruz.   +10 more
doaj   +1 more source

EXPRESSION OF PXR, MDR1, CYP3A5, AND CYP2B6 IN HIGH-GRADE SEROUS OVARIAN CANCER AND ITS SIGNIFICANCE [PDF]

精准医学杂志, 2023
Objective To investigate the expression and significance of progesterone X receptor (PXR), multidrug resistant protein 1 (MDR1), cytochrome P450 3A5 (CYP3A5), and cytochrome P450 2B6 (CYP2B6) in high-grade serous ovarian cancer (HGSOC).
ZHANG Ping, MA Lan, CHEN Hua
doaj   +1 more source

Haplotypes frequencies of CYP2B6 in Malaysia

Journal of Postgraduate Medicine, 2012
Background: Drugs with complex pharmacology are used in the management of drug use disorder (DUD) and HIV/AIDS in Malaysia and in parts of South-East Asia. Their multiethnic populations suggest complexity due to the genetic polymorphism, such as CYP2B6 that metabolizes methadone and anti-retroviral.
N, Musa, M I, Zulkafli, N, Talib, N, Mohamad, H, Fauzi, R, Ismail   +5 more
openaire   +2 more sources

Distribution of CYP2B6 516G/T pharmacogenetically important polymorphism in the Ukrainian population

Saudi Pharmaceutical Journal, 2018
The CYP2B6 is one of the members of the cytochrome P450 superfamily. This enzyme metabolizes a number of currently prescribed drugs and different compounds.
Olga Filiptsova, Marina Kobets, Julia Kobets, Olga Naboka, Olga Koiro, Alexandr Ochkur, Larisa Galiy   +6 more
doaj   +1 more source

Allelic variants of CYP2B6 gene expression and its implication on the pathogenesis of malaria among a cohort of outpatients in North-Central Nigeria

Open Health, 2023
Human cytochrome P450 2B6 (CYP2B6) is fortified with the biotransformation of the antimalarial, artemisinin combination therapy (ACT). Owing to emerging reports of Plasmodium species resistance to ACT in other climes, CYP2B6*6 genotype significantly ...
Shittu Olalere, Oniya Mobolanle Oladipo, Olusi Titus Adeniyi   +2 more
doaj   +1 more source

Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection

International Journal of Infectious Diseases, 2019
Background: The cytochrome P450 CYP2B6*6 (CYP2B6 c.516G>T; rs3745274) is one of the genetic factors that alters the drug metabolism in antimalarial, antiretroviral and TB first-line drugs.
Simon Marie Peko, Nerly Shirère Gampio Gueye, Christevy Vouvoungui, Félix Koukouikila-Koussounda, Simon Charles Kobawila, David Nderu, Thirumalaisamy P. Velavan, Francine Ntoumi   +7 more
doaj   +1 more source

Differences in Methadone Metabolism by CYP2B6 Variants [PDF]

Drug Metabolism and Disposition, 2015
Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N-demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP).
Sarah, Gadel, Christina, Friedel, Evan D, Kharasch   +2 more
openaire   +2 more sources

Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate. [PDF]

PLoS ONE, 2013
This study investigated the effects of pregnane X receptor (PXR/NR1I2) and CYP2B6 genetic variants on sodium ferulate (SF)-mediated induction of bupropion hydroxylation.
Lichen Gao, Yijing He, Jie Tang, Jiye Yin, Zhengyu Huang, Fangqun Liu, Dongsheng Ouyang, Xiaoping Chen, Wei Zhang, Zhaoqian Liu, Honghao Zhou   +10 more
doaj   +1 more source

Genetic and non‐genetic factors influencing efavirenz population pharmacokinetics among human immunodeficiency virus‐1‐infected children in Ethiopia

CPT: Pharmacometrics & Systems Pharmacology, 2023
Despite the potential for efavirenz (EFV) to be an effective alternative antiretroviral agent, its sources of wide inter‐ and intra‐individual pharmacokinetic (PK) variability are not well‐characterized in children. We investigated the effects of genetic
Adugna Chala, Eliford Ngaimisi Kitabi, Jemal Hussien Ahmed, Birkneh Tilahun Tadesse, Tolossa Eticha Chaka, Eyasu Makonnen, Eleni Aklillu   +6 more
doaj   +1 more source