Results 31 to 40 of about 52,753 (266)

Late-onset efavirenz toxicity: A descriptive study from Pretoria, South Africa

Southern African Journal of HIV Medicine, 2023
Background: The neuropsychiatric side effects of efavirenz occur mainly early during treatment and are usually mild. A lesser-known and serious complication is late-onset efavirenz toxicity causing ataxia and encephalopathy. Data regarding this condition
Lyneshree Munsami, Clara M. Schutte, Maryke de Villiers, Juliane Hiesgen   +3 more
doaj   +1 more source

Nevirapine- and efavirenz-associated hepatotoxicity under programmatic conditions in Kenya and Mozambique. [PDF]

, 2012
To describe the frequency, risk factors, and clinical signs and symptoms associated with hepatotoxicity (HT) in patients on nevirapine- or efavirenz-based antiretroviral therapy (ART), we conducted a retrospective cohort analysis of patients attending ...
Biot, M, Chu, K M, Ford, N P, Manzi, M, Rasschaert, F, Zachariah, R, Zuniga, I   +6 more
core   +2 more sources

Efavirenz

Reactions Weekly, 2006
europepmc   +5 more sources

Drug resistance outcomes of long-term ART with tenofovir disoproxil fumarate in the absence of virological monitoring [PDF]

, 2018
Objectives: The resistance profiles of patients receiving long-term ART in sub-Saharan Africa have been poorly described. This study obtained a sensitive assessment of the resistance patterns associated with long-term tenofovir-based ART in a ...
Appiah, Lambert T, Beloukas, Apostolos, Chadwick, David, Geretti, Anna Maria, Phillips, Richard O, Ruggiero, Alessandra, Sarfo, Fred S, Smith, Colette, Stockdale, Alexander J, Villa, Giovanni   +9 more
core   +3 more sources

Altered Gut Microbiome under Antiretroviral Therapy: Impact of Efavirenz and Zidovudine

ACS Infectious Diseases, 2020
Millions of individuals currently living with HIV globally are receiving antiretroviral therapy (ART) that suppresses viral replication and improves host immune responses.
S. Ray, Aswathy Narayanan, C. Giske, U. Neogi, A. Sönnerborg, P. Nowak   +5 more
semanticscholar   +1 more source

Short Term Stability Testing of Efavirenz-Loaded Solid Lipid Nanoparticle (SLN) and Nanostructured Lipid Carrier (NLC) Dispersions

Pharmaceutics, 2019
The short term stability of efavirenz-loaded solid lipid nanoparticle and nanostructured lipid carrier dispersions was investigated. Hot High Pressure Homogenization with the capability for scale up production was successfully used to manufacture the ...
P. Makoni, K. Wa Kasongo, R. B. Walker
semanticscholar   +1 more source

Blood-based Alzheimer's disease biomarkers and cognitive trajectories in older people with HIV with undetectable viral loads. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Cognitive impairment among people with HIV (PWH) remains common, yet underlying mechanisms remain unclear. Alzheimer's disease (AD) is the leading cause of dementia, and blood‐based biomarkers offer a promising diagnostic alternative.
Hiransuthikul A, Thanapornsangsuth P, Luechaipanit W, Haethaisong T, Ubolyam S, Apornpong T, Han WM, Kerr S, Avihingsanon A, HIV‐NAT 006 and 207 study team.   +9 more
europepmc   +2 more sources

Implementing a tenofovir-based first-line regimen in rural Lesotho: clinical outcomes and toxicities after two years. [PDF]

, 2011
The latest World Health Organization guidelines recommend replacing stavudine with tenofovir or zidovudine in first-line antiretroviral therapy in resource-limited settings.
Birkus, Brinkman, Callaghan, Cohen, Davidson, Ford, Gallant, Gallant, Grim, Hawkins, Mills, Pozniak, Stone   +12 more
core   +2 more sources

Pharmacokinetics and Drug‐Drug Interactions of Isoniazid and Efavirenz in Pregnant Women Living With HIV in High TB Incidence Settings: Importance of Genotyping

Clinical pharmacology and therapy, 2020
The World Health Organization guidelines recommend that individuals living with HIV receive ≥ 6 months of isoniazid preventive therapy, including pregnant women.
Kamunkhwala Gausi, L. Wiesner, J. Norman, C. Wallis, Carolyne Onyango-Makumbi, T. Chipato, D. Haas, R. Browning, N. Chakhtoura, G. Montepiedra, L. Aaron, K. McCarthy, Sarah Bradford, Tichaona Vhembo, L. Stranix-Chibanda, G. Masheto, A. Violari, B. Mmbaga, L. Aurpibul, R. Bhosale, Neetal Nevrekhar, V. Rouzier, Enid Kabugho, M. Mutambanengwe, V. Chanaiwa, M. Nyati, T. Mhembere, F. Tongprasert, A. Hesseling, Katherine Shin, B. Zimmer, Diane G. Costello, P. Jean‐Philippe, T. Sterling, G. Theron, A. Weinberg, Amita Gupta, P. Denti   +37 more
semanticscholar   +1 more source

Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats

Scientific Reports, 2018
Efavirenz is abused in a cannabis-containing mixture known as Nyaope. The addictive-like effects of efavirenz (5, 10 and 20 mg/kg) was explored using conditioned place preference (CPP) in rats following sub-acute exposure vs. methamphetamine (MA; 1 mg/kg)
Marisa Möller, Jaco Fourie, Brian H. Harvey   +2 more
doaj   +1 more source