Results 11 to 20 of about 20,043 (161)

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Variability of efavirenz plasma concentrations among pediatric HIV patients treated with efavirenz based combination antiretroviral therapy in Dar es Salaam, Tanzania

BMC Pharmacology and Toxicology, 2018
Background Children are subject to varying drug pharmacokinetics which influence plasma drug levels, and hence treatment outcomes especially for drugs like efavirenz whose plasma concentrations are directly related to treatment outcomes.
Selemani Saidi Sungi, Eliford Ngaimisi, Nzovu Ulenga, Philip Sasi, Sabina Mugusi   +4 more
doaj   +1 more source

Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats

Scientific Reports, 2018
Efavirenz is abused in a cannabis-containing mixture known as Nyaope. The addictive-like effects of efavirenz (5, 10 and 20 mg/kg) was explored using conditioned place preference (CPP) in rats following sub-acute exposure vs. methamphetamine (MA; 1 mg/kg)
Marisa Möller, Jaco Fourie, Brian H. Harvey   +2 more
doaj   +1 more source

ABCB1 4036A>G and 1236C>T polymorphisms affect plasma efavirenz levels in South African HIV/AIDS patients

Frontiers in Genetics, 2012
The ABCB1 gene encodes P-glycoprotein, an ATP-dependent drug efflux pump, which is responsible for drug transport across extra- and intra-cellular membranes.
Marelize eSwart, Yuan eRen, Peter eSmith, Collet eDandara   +3 more
doaj   +1 more source

Influence of milling process on efavirenz solubility

Journal of Pharmacy and Bioallied Sciences, 2017
Introduction: The aim of this study was to investigate the influence of the milling process on the solubility of efavirenz. Materials and Methods: Milling process was done using Nanomilling for 30, 60, and 180 min.
Erizal Zaini, Deni Wahyu, Maria Dona Octavia, Lili Fitriani   +3 more
doaj   +1 more source

CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

Clinical and Translational Science, 2019
We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe.
Ingrid F. Metzger, Nimita Dave, Yvonne Kreutz, Jessica B.L. Lu, Raymond E. Galinsky, Zeruesenay Desta   +5 more
doaj   +1 more source

Efavirenz use during pregnancy and for women of child-bearing potential

AIDS Research and Therapy, 2006
Background Efavirenz is the preferred non-nucleoside reverse transcriptase inhibitor for first-line antiretroviral treatment in many countries. For women of childbearing potential, advantages of efavirenz are balanced by concerns that it is teratogenic ...
Gray Glenda E, Krause Amanda, Wessels Tina, Venter Francois WD, Urban Michael F, Chersich Matthew F, Luchters Stanley, Viljoen Dennis L   +7 more
doaj   +1 more source

Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis. [PDF]

PLoS ONE, 2011
WHO recommends starting therapy with a non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs), i.e. nevirapine or efavirenz, with lamivudine or emtricitabine, plus zidovudine or tenofovir.
Nicole Ngo-Giang-Huong, Gonzague Jourdain, Billy Amzal, Pensiriwan Sang-a-gad, Rittha Lertkoonalak, Naree Eiamsirikit, Somboon Tansuphasawasdikul, Yuwadee Buranawanitchakorn, Naruepon Yutthakasemsunt, Sripetcharat Mekviwattanawong, Kenneth McIntosh, Marc Lallemant, Program for HIV Prevention and Treatment (PHPT) study group   +12 more
doaj   +1 more source

Histopathological effect of co-administration of efavirenz and vitamin E on the liver, and biochemical parameters in wistar rats

Asian Journal of Medical Sciences, 2016
Background: Efavirenz is a drug used in combination as highly active antiretroviral therapy (HAART) used for the treatment of human immunodeficiency virus (HIV).
Aniekan I Peter
doaj   +1 more source

A simple high-performance liquid chromatographic assay for concurrent quantification of lumefantrine and efavirenz in human plasma from malaria–HIV co-infected individuals

Future Journal of Pharmaceutical Sciences, 2023
Background As per current treatment guidelines, artemether-lumefantrine and efavirenz-based antiretroviral therapy are recommended drugs for falciparum malaria and human immunodeficiency virus (HIV) infections, respectively.
Adebanjo J. Adegbola, Ruth M. Ogboye, Julius O. Soyinka, Oluseye O. Bolaji   +3 more
doaj   +1 more source