Results 11 to 20 of about 20,432 (139)

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications. [PDF]

Br J Clin Pharmacol
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Kiguba R, Ssesanga M, Pirmohamed M.
europepmc   +2 more sources

Impact of Efavirenz on Heme Protein Induction and Biomarkers: Insights From In Vitro Experiments and a Clinical Study [PDF]

Clinical and Translational Science
Coproporphyrin I (CPI) is increasingly recognized as a reliable endogenous biomarker for hepatic OATP1B transporters. However, confounding mechanisms such as increased heme biosynthesis driven by induction of CYP enzymes, which are hemoproteins, may ...
Leila Potzel, Jonny Kinzi, Isabell Seibert, Markus Grube, Werner Siegmund, Henriette E. Meyer zu Schwabedissen   +5 more
doaj   +2 more sources

Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug-Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray. [PDF]

Clin Pharmacol Ther
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Ke A, Callegari E, Varma MVS, Ladumor MK, Muto C, Bertz RJ, Jones HM, Sahasrabudhe V, Liu J.   +8 more
europepmc   +2 more sources

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

ABCB1 4036A>G and 1236C>T polymorphisms affect plasma efavirenz levels in South African HIV/AIDS patients

Frontiers in Genetics, 2012
The ABCB1 gene encodes P-glycoprotein, an ATP-dependent drug efflux pump, which is responsible for drug transport across extra- and intra-cellular membranes.
Marelize eSwart, Yuan eRen, Peter eSmith, Collet eDandara   +3 more
doaj   +1 more source

Influence of milling process on efavirenz solubility

Journal of Pharmacy and Bioallied Sciences, 2017
Introduction: The aim of this study was to investigate the influence of the milling process on the solubility of efavirenz. Materials and Methods: Milling process was done using Nanomilling for 30, 60, and 180 min.
Erizal Zaini, Deni Wahyu, Maria Dona Octavia, Lili Fitriani   +3 more
doaj   +1 more source

CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

Clinical and Translational Science, 2019
We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe.
Ingrid F. Metzger, Nimita Dave, Yvonne Kreutz, Jessica B.L. Lu, Raymond E. Galinsky, Zeruesenay Desta   +5 more
doaj   +1 more source

Efavirenz use during pregnancy and for women of child-bearing potential

AIDS Research and Therapy, 2006
Background Efavirenz is the preferred non-nucleoside reverse transcriptase inhibitor for first-line antiretroviral treatment in many countries. For women of childbearing potential, advantages of efavirenz are balanced by concerns that it is teratogenic ...
Gray Glenda E, Krause Amanda, Wessels Tina, Venter Francois WD, Urban Michael F, Chersich Matthew F, Luchters Stanley, Viljoen Dennis L   +7 more
doaj   +1 more source

Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis. [PDF]

PLoS ONE, 2011
WHO recommends starting therapy with a non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs), i.e. nevirapine or efavirenz, with lamivudine or emtricitabine, plus zidovudine or tenofovir.
Nicole Ngo-Giang-Huong, Gonzague Jourdain, Billy Amzal, Pensiriwan Sang-a-gad, Rittha Lertkoonalak, Naree Eiamsirikit, Somboon Tansuphasawasdikul, Yuwadee Buranawanitchakorn, Naruepon Yutthakasemsunt, Sripetcharat Mekviwattanawong, Kenneth McIntosh, Marc Lallemant, Program for HIV Prevention and Treatment (PHPT) study group   +12 more
doaj   +1 more source

Histopathological effect of co-administration of efavirenz and vitamin E on the liver, and biochemical parameters in wistar rats

Asian Journal of Medical Sciences, 2016
Background: Efavirenz is a drug used in combination as highly active antiretroviral therapy (HAART) used for the treatment of human immunodeficiency virus (HIV).
Aniekan I Peter
doaj   +1 more source