Results 11 to 20 of about 40,504 (198)

The Burden of Adverse Drug Reactions in Africa in the Context of Pharmacogenetics-Based Clinical Guidelines. [PDF]

Clin Pharmacol Ther
Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Scholefield J, Mazhindu TA, Nagy M, Twesigomwe D, Agesa G, Masimirembwa C.   +5 more
europepmc   +2 more sources

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Late-onset efavirenz toxicity: A descriptive study from Pretoria, South Africa

Southern African Journal of HIV Medicine, 2023
Background: The neuropsychiatric side effects of efavirenz occur mainly early during treatment and are usually mild. A lesser-known and serious complication is late-onset efavirenz toxicity causing ataxia and encephalopathy. Data regarding this condition
Lyneshree Munsami, Clara M. Schutte, Maryke de Villiers, Juliane Hiesgen   +3 more
doaj   +1 more source

Nevirapine- and efavirenz-associated hepatotoxicity under programmatic conditions in Kenya and Mozambique. [PDF]

, 2012
To describe the frequency, risk factors, and clinical signs and symptoms associated with hepatotoxicity (HT) in patients on nevirapine- or efavirenz-based antiretroviral therapy (ART), we conducted a retrospective cohort analysis of patients attending ...
Biot, M, Chu, K M, Ford, N P, Manzi, M, Rasschaert, F, Zachariah, R, Zuniga, I   +6 more
core   +2 more sources

PKRxiv: A Best Practice Model for Advancing Pharmacoequity Through Open Pharmacokinetic Data Sharing. [PDF]

Clin Pharmacol Ther
Model‐informed drug development is increasingly integrated across the drug development continuum, enabling more efficient, cost‐effective, and targeted trials while reducing reliance on animal studies. Achieving pharmacoequity requires not only equitable access to medicines but also to the data and knowledge that inform drug development and regulatory ...
Atoyebi S, Venkatasubramanian P, Akinloye A, Eniayewu O, Best BM, Else L, Olagunju A.   +6 more
europepmc   +2 more sources

The utility of efavirenz-based prophylaxis against HIV infection. A systems pharmacological analysis [PDF]

, 2019
Pre-exposure prophylaxis (PrEP) is considered one of the five “pillars” by UNAIDS to reduce HIV transmission. Moreover, it is a tool for female self-protection against HIV, making it highly relevant to sub-Saharan regions, where women have the highest ...
Dickinson, Laura, Duwal, Sulav, Khoo, Saye, Kleist, Max von, Seeler, Daniel   +4 more
core   +4 more sources

Positive Outcomes of HAART at 24 Months in HIV-Infected Patients in Cambodia. [PDF]

, 2007
OBJECTIVES: African and Asian cohort studies have demonstrated the feasibility and efficacy of HAART in resource-poor settings. The long-term virological outcome and clinico-immunological criteria of success remain important questions.
Bartlett, Bartlett, Bourgeois, Calmy, Calmy, Carrieri, Carrieri, Coetzee, Colebunders, Colebunders, Dabis, Ferradini, Gill, Gonzalez de, Grabar, Ivers, Kumarasamy, Laurent, Laurent, Lawn, Lawn, Lawn, Le Moing, Ly, Madec, Marzolini, Orrell, Pasquier, Rouet, Rouzioux, Severe, Tassie, Van Heeswijk, Weidle, Wu, Zhou   +35 more
core   +2 more sources

Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats

Scientific Reports, 2018
Efavirenz is abused in a cannabis-containing mixture known as Nyaope. The addictive-like effects of efavirenz (5, 10 and 20 mg/kg) was explored using conditioned place preference (CPP) in rats following sub-acute exposure vs. methamphetamine (MA; 1 mg/kg)
Marisa Möller, Jaco Fourie, Brian H. Harvey   +2 more
doaj   +1 more source

Variability of efavirenz plasma concentrations among pediatric HIV patients treated with efavirenz based combination antiretroviral therapy in Dar es Salaam, Tanzania

BMC Pharmacology and Toxicology, 2018
Background Children are subject to varying drug pharmacokinetics which influence plasma drug levels, and hence treatment outcomes especially for drugs like efavirenz whose plasma concentrations are directly related to treatment outcomes.
Selemani Saidi Sungi, Eliford Ngaimisi, Nzovu Ulenga, Philip Sasi, Sabina Mugusi   +4 more
doaj   +1 more source

Personalizing HIV therapy, mission impossible? [PDF]

, 2012
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core   +1 more source