Results 31 to 40 of about 40,504 (198)

A simple high-performance liquid chromatographic assay for concurrent quantification of lumefantrine and efavirenz in human plasma from malaria–HIV co-infected individuals

Future Journal of Pharmaceutical Sciences, 2023
Background As per current treatment guidelines, artemether-lumefantrine and efavirenz-based antiretroviral therapy are recommended drugs for falciparum malaria and human immunodeficiency virus (HIV) infections, respectively.
Adebanjo J. Adegbola, Ruth M. Ogboye, Julius O. Soyinka, Oluseye O. Bolaji   +3 more
doaj   +1 more source

Drug-Drug Interactions Among Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Medications [PDF]

, 2015
One-fourth of individuals diagnosed with the human immunodeficiency virus concomitantly have the hepatitis C virus infection. Since the discovery of highly active antiretroviral therapy, liver complications have become the leading cause of morbidity and ...
Gandhi, Mona A., Kaur, Kirpal, Slish, Judianne   +2 more
core   +2 more sources

Chronic toxicity and environmental risk assessment of antivirals in Ceriodaphnia dubia and Raphidocelis subcapitata

Water Science and Technology, 2021
Antiviral drugs are a class of medications used for treating viral infections. Due to their widespread use, especially in cases of pandemics and limited human metabolism, antivirals have been detected in multiple environmental matrices.
L. C. Almeida, A. C. Mattos, C. P. G. Dinamarco, N. G. Figueiredo, D. M. Bila   +4 more
doaj   +1 more source

Preferred antiretroviral drugs for the next decade of scale up [PDF]

, 2012
Global commitments aim to provide antiretroviral therapy (ART) to 15 million people living with HIV by 2015, and recent studies have demonstrated the potential for widespread ART to prevent HIV transmission.
Andrieux-Meyer, Isabelle, Cahn, Pedro, Calmy, Alexandra, Clayden, Polly, Ford, Nathan, Goemaere, Eric, Katlama, Christine, Levin, Andrew, Lynch, Sharonann, Raguin, Gilles, Vitoria, Marco   +10 more
core   +4 more sources

Effect of Efavirenz on UDP-Glucuronosyltransferase 1A1, 1A4, 1A6, and 1A9 Activities in Human Liver Microsomes

Molecules, 2012
Efavirenz is a non-nucleoside reverse transcriptase inhibitor used for the treatment of human immunodeficiency virus type 1 infections. Drug interactions of efavirenz have been reported due to in vitro inhibition of CYP2C9, CYP2C19, CYP3A4, and UDP ...
Hye Suk Lee, Hyeri Lee, Sae Rom Lim, Jeong Han Kim, Hye Young Ji   +4 more
doaj   +1 more source

Focus on chirality of HIV-​1 non-​nucleoside reverse transcriptase inhibitors [PDF]

, 2016
Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug resistant mutant strains.
Famiglini, Valeria, Silvestri, Romano
core   +2 more sources

Pharmacokinetics, pharmacogenetics, and toxicity of co-administered efavirenz and isoniazid

Southern African Journal of HIV Medicine
Background: CYP2B6 slow metabolisers have higher efavirenz concentrations, which are further increased by isoniazid inhibiting efavirenz’s accessory metabolic pathway.
Jessica Taylor, Gary Maartens, Simiso Sokhela, Nomathemba Chandiwana, Godspower Akpomiemie, Francois Venter, Phumla Sinxadi   +6 more
doaj   +1 more source

Differences in response to antiretroviral therapy in HIV-positive patients being treated for tuberculosis in Eastern Europe, Western Europe and Latin America

BMC Infectious Diseases, 2018
Background Efavirenz-based antiretroviral therapy (ART) regimens are preferred for treatment of adult HIV-positive patients co-infected with tuberculosis (HIV/TB).
Yanink Caro-Vega, Anna Schultze, Anne Marie W. Efsen, Frank A. Post, Alexander Panteleev, Aliaksandr Skrahin, Jose M. Miro, Enrico Girardi, Daria N. Podlekareva, Jens D. Lundgren, Juan Sierra-Madero, Javier Toibaro, Jaime Andrade-Villanueva, Simona Tetradov, Jan Fehr, Joan Caylà, Marcelo H. Losso, Robert F. Miller, Amanda Mocroft, Ole Kirk, Brenda Crabtree-Ramírez   +20 more
doaj   +1 more source

Developmental abnormalities and growth patterns in juvenile Oreochromis mossambicus chronically exposed to efavirenz

Emerging Contaminants, 2022
Efavirenz is an antiretroviral drug (ARV) used for the treatment of Human Immunodeficiency Virus (HIV/AIDS) infections. The effects efavirenz may have on mammals is known, however, little is known about the effects on non-target aquatic organisms ...
Saisha Kowlaser, Irene Barnhoorn, Ina Wagenaar   +2 more
doaj   +1 more source

Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW). [PDF]

, 2016
We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-
Amico, K Rivet, Avelino-Silva, Vivian I, Burns, David, Chodacki, Piotr, Defechereux, Patricia A, Fernandez, Telmo, Glidden, David V, Grant, Robert M, iPrEx Study Team, Liu, Albert Y, Mayer, Kenneth H, McMahan, Vanessa M, Mehrotra, Megha, Vargas, Lorena   +13 more
core   +1 more source