Results 31 to 40 of about 28,830 (241)

Efavirenz use during pregnancy and for women of child-bearing potential

AIDS Research and Therapy, 2006
Background Efavirenz is the preferred non-nucleoside reverse transcriptase inhibitor for first-line antiretroviral treatment in many countries. For women of childbearing potential, advantages of efavirenz are balanced by concerns that it is teratogenic ...
Gray Glenda E, Krause Amanda, Wessels Tina, Venter Francois WD, Urban Michael F, Chersich Matthew F, Luchters Stanley, Viljoen Dennis L   +7 more
doaj   +1 more source

Histopathological effect of co-administration of efavirenz and vitamin E on the liver, and biochemical parameters in wistar rats

Asian Journal of Medical Sciences, 2016
Background: Efavirenz is a drug used in combination as highly active antiretroviral therapy (HAART) used for the treatment of human immunodeficiency virus (HIV).
Aniekan I Peter
doaj   +1 more source

A simple high-performance liquid chromatographic assay for concurrent quantification of lumefantrine and efavirenz in human plasma from malaria–HIV co-infected individuals

Future Journal of Pharmaceutical Sciences, 2023
Background As per current treatment guidelines, artemether-lumefantrine and efavirenz-based antiretroviral therapy are recommended drugs for falciparum malaria and human immunodeficiency virus (HIV) infections, respectively.
Adebanjo J. Adegbola, Ruth M. Ogboye, Julius O. Soyinka, Oluseye O. Bolaji   +3 more
doaj   +1 more source

Chronic toxicity and environmental risk assessment of antivirals in Ceriodaphnia dubia and Raphidocelis subcapitata

Water Science and Technology, 2021
Antiviral drugs are a class of medications used for treating viral infections. Due to their widespread use, especially in cases of pandemics and limited human metabolism, antivirals have been detected in multiple environmental matrices.
L. C. Almeida, A. C. Mattos, C. P. G. Dinamarco, N. G. Figueiredo, D. M. Bila   +4 more
doaj   +1 more source

Differences in response to antiretroviral therapy in HIV-positive patients being treated for tuberculosis in Eastern Europe, Western Europe and Latin America

BMC Infectious Diseases, 2018
Background Efavirenz-based antiretroviral therapy (ART) regimens are preferred for treatment of adult HIV-positive patients co-infected with tuberculosis (HIV/TB).
Yanink Caro-Vega, Anna Schultze, Anne Marie W. Efsen, Frank A. Post, Alexander Panteleev, Aliaksandr Skrahin, Jose M. Miro, Enrico Girardi, Daria N. Podlekareva, Jens D. Lundgren, Juan Sierra-Madero, Javier Toibaro, Jaime Andrade-Villanueva, Simona Tetradov, Jan Fehr, Joan Caylà, Marcelo H. Losso, Robert F. Miller, Amanda Mocroft, Ole Kirk, Brenda Crabtree-Ramírez   +20 more
doaj   +1 more source

Developmental abnormalities and growth patterns in juvenile Oreochromis mossambicus chronically exposed to efavirenz

Emerging Contaminants, 2022
Efavirenz is an antiretroviral drug (ARV) used for the treatment of Human Immunodeficiency Virus (HIV/AIDS) infections. The effects efavirenz may have on mammals is known, however, little is known about the effects on non-target aquatic organisms ...
Saisha Kowlaser, Irene Barnhoorn, Ina Wagenaar   +2 more
doaj   +1 more source

Substantial Effect of Efavirenz Monotherapy on Bilirubin Levels in Healthy Volunteers

Current Therapeutic Research, 2014
Background: Efavirenz exhibits multiple interactions with drug-metabolizing enzymes and transporters, and for this reason efavirenz-based HIV therapy is associated with altered pharmacokinetics of coadministered drugs.
Ingrid F. Metzger, PhD, Troy C. Quigg, MD, Noam Epstein, Abdulateef O. Aregbe, MD, Nancy Thong, John T. Callaghan, MD, PhD, David A. Flockhart, MD, PhD, Anne T. Nguyen, Colleen K. Stevens, Samir K. Gupta, Zeruesenay Desta, PhD   +10 more
doaj   +1 more source

Therapeutic drug monitoring and pharmacogenetic study of HIV-infected ethnic Chinese receiving efavirenz-containing antiretroviral therapy with or without rifampicin-based anti-tuberculous therapy. [PDF]

PLoS ONE, 2014
OBJECTIVES: Plasma efavirenz concentrations in HIV-infected patients with tuberculosis (TB) may be affected by cytochrome P450 (CYP) 2B6 single-nucleotide polymorphisms and concurrent rifampicin use.
Kuan-Yeh Lee, Shu-Wen Lin, Hsin-Yun Sun, Ching-Hua Kuo, Mao-Song Tsai, Bing-Ru Wu, Sue-Yo Tang, Wen-Chun Liu, Sui-Yuan Chang, Chien-Ching Hung   +9 more
doaj   +1 more source

Cholesterol content in OHCs from control, efavirenz, and efavirenz plus phytosterols-treated mice.

, 2023
(A) Representative confocal images of whole mounts organ of Corti from the OHCs’ area of the basal region stained with phalloidin (blue; to visualize actin in stereocilia) and filipin (green; to label cholesterol) in control, treated with efavirenz, and ...
María A. Paulazo (8356731), Alejandro O. Sodero (8356734), María Eugenia Gomez-Casati (16877076), Jimena A. Ballestero (16877070), Mauricio G. Martin (16877073), Setiembre D. Elorza (16877064), Sara M. Gonzalez-Rodulfo (16877067), Valeria C. Castagna (16877061)   +7 more
core   +1 more source

Pharmacokinetic interactions between rifampicin and efavirenz in HIV-TB coinfections [PDF]

Universa Medicina, 2009
The increased percentage of patients with HIV-TB coinfection leads to inevitable interactions between rifampicin and efavirenz. Efavirenz is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV infection.
Yenny
doaj