Results 21 to 30 of about 40,504 (198)
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Frontiers in Genetics, 2012 The ABCB1 gene encodes P-glycoprotein, an ATP-dependent drug efflux pump, which is responsible for drug transport across extra- and intra-cellular membranes.
Marelize eSwart +3 more
doaj +1 more source
Drug resistance outcomes of long-term ART with tenofovir disoproxil fumarate in the absence of virological monitoring [PDF]
, 2018 Objectives: The resistance profiles of patients receiving long-term ART in sub-Saharan Africa have been poorly described. This study obtained a sensitive assessment of the resistance patterns associated with long-term tenofovir-based ART in a ...
Appiah, Lambert T +9 more
core +3 more sources
Interventions for neurocognitive dysfunction [PDF]
, 2017 Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core +2 more sources
Clinical and Translational Science, 2019 We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe.
Ingrid F. Metzger +5 more
doaj +1 more source
Influence of milling process on efavirenz solubility
Journal of Pharmacy and Bioallied Sciences, 2017 Introduction: The aim of this study was to investigate the influence of the milling process on the solubility of efavirenz. Materials and Methods: Milling process was done using Nanomilling for 30, 60, and 180 min.
Erizal Zaini +3 more
doaj +1 more source
Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis. [PDF]
PLoS ONE, 2011 WHO recommends starting therapy with a non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs), i.e. nevirapine or efavirenz, with lamivudine or emtricitabine, plus zidovudine or tenofovir.
Nicole Ngo-Giang-Huong +12 more
doaj +1 more source
Implementing a tenofovir-based first-line regimen in rural Lesotho: clinical outcomes and toxicities after two years. [PDF]
, 2011 The latest World Health Organization guidelines recommend replacing stavudine with tenofovir or zidovudine in first-line antiretroviral therapy in resource-limited settings.
Birkus +12 more
core +2 more sources
Efavirenz use during pregnancy and for women of child-bearing potential
AIDS Research and Therapy, 2006 Background Efavirenz is the preferred non-nucleoside reverse transcriptase inhibitor for first-line antiretroviral treatment in many countries. For women of childbearing potential, advantages of efavirenz are balanced by concerns that it is teratogenic ...
Gray Glenda E +7 more
doaj +1 more source
Asian Journal of Medical Sciences, 2016 Background: Efavirenz is a drug used in combination as highly active antiretroviral therapy (HAART) used for the treatment of human immunodeficiency virus (HIV).
Aniekan I Peter
doaj +1 more source