Results 61 to 70 of about 581,012 (280)

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

Biomolecules, 2021
Usnic acid (UA) is a secondary metabolite of lichens that exhibits a wide range of biological activities. Previously, we found that UA derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 (TDP1).
Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Alexandra L. Zakharenko, Ekaterina S. Ilina, Anastasia A. Malakhova, Sergey P. Medvedev, Jóhannes Reynisson, Konstantin P. Volcho, Suren M. Zakian, Nariman F. Salakhutdinov, Olga I. Lavrik   +11 more
doaj   +1 more source

Isospin effects and symmetry energy studies with INDRA

, 2013
The equation of state of asymmetric nuclear matter is still controversial, as predictions at subsaturation as well as above normal density widely diverge.
A.Chbihi, B.Borderie, D.Gruyer, D.Guinety, E.Galichet, E.Rosato, E.Vient, F.Gagnon-Moisan, G.Ademard, G.Lehaut, G.Spadaccini, J.D.Frankland, J.P.Wieleczko, M.Boisjoli, M.F.Rivet, M.Kabtoul, M.La Commara, M.Pârlog, M.Vigilante, N.Le Neindre, O.Lopez, P. Marini, P.Lautesse, P.Napolitani, P.Pawlowski, R.Bougault, R.Bougault, R.Roy   +27 more
core   +3 more sources

Chandra's Close Encounter with the Disintegrating Comets 73P/2006 (Schwassmann--Wachmann--3) Fragment B and C/1999 S4 (LINEAR) [PDF]

, 2008
On May 23, 2006 we used the ACIS-S instrument on the Chandra X-ray Observatory (CXO) to study the X-ray emission from the B fragment of comet 73P/2006 (Schwassmann-Wachmann 3) (73P/B).
Arnaud, Bodewits, Bodewits, Bodewits, Bohnhardt, C. M. Lisse, Cravens, D. Bodewits, D. J. Christian, Festou, Flammer, Haser, Horanyi, Ip, Johnstone, K. Dennerl, Kharchenko, Koutroumpa, Lisse, Lisse, Lisse, McCammon, Pepino, Reach, S. J. Wolk, Sasseen, Schleicher, Schwadron, Villanueva, Weaver   +29 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Rapid screening of 420 pesticide residues in fruits and vegetables using ultra high performance liquid chromatography combined with quadrupole-time of flight mass spectrometry

Food Science and Human Wellness, 2023
A new method for screening and identification 420 pesticide residues in fruits and vegetables by ultra-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UPLC-Q-TOF/MS) were developed.
Junmei Ma, Sufang Fan, Liqiong Yang, Liangna He, Hongwen Zhai, Xiaowei Ren, Qiang Li, Yan Zhang   +7 more
doaj   +1 more source

Reaction Dynamics with Exotic Beams

, 2004
We review the new possibilities offered by the reaction dynamics of asymmetric heavy ion collisions, using stable and unstable beams. We show that it represents a rather unique tool to probe regions of highly Asymmetric Nuclear Matter ($ANM$) in ...
Baran, V., Colonna, M., Di Toro, M., Greco, V.   +3 more
core   +1 more source

The Mass-Size Relation from Clouds to Cores. I. A new Probe of Structure in Molecular Clouds [PDF]

, 2010
We use a new contour-based map analysis technique to measure the mass and size of molecular cloud fragments continuously over a wide range of spatial scales (0.05 < r / pc < 10), i.e., from the scale of dense cores to those of entire clouds.
A. A. Goodman, Ballesteros-Paredes, Cambrésy, Cernis, Enoch, Enoch, Goodman, J. Kauffmann, Johnstone, Kauffmann, Kirk, Larson, Motte, Ossenkopf, P. C. Myers, Pineda, R. Shetty, Ridge, Rosolowsky, Rosolowsky, Shetty, T. Pillai, Tan, Williams   +23 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Anisotropic fragmentation in low-energy dissociative recombination [PDF]

, 2008
On a dense energy grid reaching up to 75 meV electron collision energy the fragmentation angle and the kinetic energy release of neutral dissociative recombination fragments have been studied in a twin merged beam experiment.
A Petrignani, A S Jaroshevich, A Wolf, B Jordon-Thaden, Bardsley J N, C Krantz, D A Orlov, D Schwalm, D Shafir, D Zajfman, F O Waffeu Tamo, F O Waffeu Tamo, H Buhr, H Rubinstein, I F Schneider, J Hoffmann, M B Mendes, M Froese, M Grieser, M H Berg, M Lange, M Lestinsky, O Novotný, Orlov D A, S Novotny, Schneider I F, Shafir D, Takagi H   +27 more
core   +1 more source