Results 101 to 110 of about 3,891,523 (334)

Neutral Evolution as Diffusion in phenotype space: reproduction with mutation but without selection

, 2007
The process of `Evolutionary Diffusion', i.e. reproduction with local mutation but without selection in a biological population, resembles standard Diffusion in many ways.
A. Winter, B. Derrida, B. Rannala, D. Kannan, Daniel John Lawson, G. Slade, Henrik Jeldtoft Jensen, M. Kimura, N. T. J. Bailey, P. A. P. Moran, S. Gavrilets, S. Hubbell, T. Ohta, W. Paul   +13 more
core   +2 more sources

Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]

, 2015
The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Dean, R, Harrison, PW, Mank, JE, Wright, AE, Zimmer, F   +4 more
core   +1 more source

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

A Nearby Analog of z~2 Compact Quiescent Galaxies with a Rotating Disk

, 2012
Recent studies have identified a population of compact quiescent galaxies at z\sim2. These galaxies are very rare today and establishing the existence of a nearby analog could allow us to study its structure in greater detail than is possible at high ...
Bezanson, Rachel, Franx, Marijn, Jiang, Fangzhou, van Dokkum, Pieter   +3 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

GCIRS 7, a pulsating M1 supergiant at the Galactic centre. Physical properties and age

, 2014
The stellar population in the central parsec of the Galaxy is dominated by an old (several Gyr) population, but young, massive stars dominate the luminosity function.
Bouquin, J. B. Le, Brandner, W., Breitfelder, J., Burtscher, L., Gillessen, S., Haubois, X., Kervella, P., Martins, F., Ott, T., Paumard, T., Perrin, G., Pfuhl, O., Pott, J. -U.   +12 more
core   +3 more sources

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

The Expected Fitness Cost of a Mutation Fixation under the One-dimensional Fisher Model [PDF]

, 2009
This paper employs Fisher’s model of adaptation to understand the expected fitness effect of fixing a mutation in a natural population. Fisher’s model in one dimension admits a closed form solution for this expected fitness effect. A combination of different
Watson, Layne T., Zhang, Liqing
core   +1 more source

Effects of nano-void density, size, and spatial population on thermal conductivity: a case study of GaN crystal

, 2012
The thermal conductivity of a crystal is sensitive to the presence of surfaces and nanoscale defects. While this opens tremendous opportunities to tailor thermal conductivity, a true "phonon engineering" of nanocrystals for a specific electronic or ...
Che J W, Klemens P G, Marmalyuk A A, Puyet M, R E Jones, X W Zhou, Yang X   +6 more
core   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source