Results 101 to 110 of about 7,592,081 (289)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Models for Metal Hydride Particle Shape, Packing, and Heat Transfer

, 2012
A multiphysics modeling approach for heat conduction in metal hydride powders is presented, including particle shape distribution, size distribution, granular packing structure, and effective thermal conductivity.
Asakuma, Beaulieu, Bershadsky, Castellanos, Checchetto, Da-Wen, Flueckiger, Fukai, Griesinger, Groisman, Hahne, Incropera, Jaoshvili, Josephy, Kennard, Kim, Klein, Kojima, Kyle C. Smith, Lee, Manley, Mujat, Napov, Notay, Notay, Ovshinsky, O’Hern, Pons, Ron, Rudman, Sakai, Schlapbach, Sen, Smith, Smith, Smith, Smith, Smith, Solomon, Sondheimer, Swartz, Sánchez, Timothy S. Fisher, Torquato, Tsotsas, Ueoka, Valverde, Yang, Yonezawa, Zhang   +49 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Assessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes. [PDF]

Acta Biotheor, 2023
Hössjer O, Laikre L, Ryman N.
europepmc   +1 more source

Large-N scaling behavior of the quantum fisher information in the Dicke model

, 2015
Quantum Fisher information (QFI) of the reduced two-atom state is employed to capture the quantum criticality of the superradiant phase transition in the Dicke model in the infinite size and finite-$N$ systems respectively.
Chen, Xiang-You, Zhang, Yu-Yu
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Effective population size in field pea

BMC Genomics
Background Effective population size (N e ) is a pivotal parameter in population genetics as it can provide information on the rate of inbreeding and the contemporary status of genetic diversity in breeding populations.
Josephine Princy Johnson, Lisa Piche, Hannah Worral, Sikiru Adeniyi Atanda, Clarice J. Coyne, Rebecca J. McGee, Kevin McPhee, Nonoy Bandillo   +7 more
doaj   +1 more source

Effective Size Reduction of the Metallic Waveguide Bandpass Filter with Metamaterial Resonators and Its 3D-Printed Version. [PDF]

Sensors (Basel), 2023
Cho J, Seo Y, Cho J, Park KY, Park J, Lee H, Kahng S.   +6 more
europepmc   +1 more source