Results 121 to 130 of about 12,043,835 (299)
Journal of the Effective Schools Project
, 2007 The Journal of the Effective Schools Project covers topics related to the member schools involved in the program.
Lindsey, Pam +1 more
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Prevention and early intervention in children and young people’s services: improving child behaviour [PDF]
, 2013 For over a decade, a group of organisations has been running more than 52 prevention and early intervention programmes throughout the island of Ireland. This Initiative funded by The Atlantic Philanthropies, sometimes in conjunction with Government and
Centre for Effective Services
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Evolutionary ApplicationsMany methods are now available to calculate Ne, but their performance varies depending on assumptions. Although simulated data are useful to discover certain types of bias, real empirical data supported by detailed known population histories allow us to ...
Laia Pérez‐Sorribes +3 more
doaj +1 more source
Journal of the Effective Schools Project
, 2010 The Journal of the Effective Schools Project covers topics related to the member schools involved in the program.
Lindsey, Pam +1 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Journal of the Effective Schools Project
, 2004 The Journal of the Effective Schools Project covers topics related to the member schools involved in the program.
Lindsey, Pam +1 more
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source