Results 101 to 110 of about 3,043,757 (303)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

Temporal moment-based effective genetic size estimates.

open access: yes, 2016
NG = number of generations between a pair of samples. Ne = effective genetic size estimate. Lower and upper 95% CI represents a 95% Confidence Interval (CI) for Ne estimated for each pair of samples. Ne/Nc ratio = ratio between effective population size (
Tatiana Fioravanti (2609869)   +12 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Effective population size in field pea

open access: yesBMC Genomics
Background Effective population size (N e ) is a pivotal parameter in population genetics as it can provide information on the rate of inbreeding and the contemporary status of genetic diversity in breeding populations.
Josephine Princy Johnson   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Effective size in simple metapopulation models

open access: yes, 2003
International audienceA coalescent argument is used to derive the effective size in simple models with recurrent local extinctions. Several alternative methods of derivation of this result are given and compared to earlier analyses of this problem.
F Rousset, Rousset, Francois
core   +1 more source

Recent human effective population size estimated from linkage disequilibrium [PDF]

open access: yes, 2007
Effective population size (N(e)) determines the amount of genetic variation, genetic drift, and linkage disequilibrium (LD) in populations. Here, we present the first genome-wide estimates of human effective population size from LD data.
Tenesa, Albert   +12 more
core   +1 more source

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