Inbreeding depression in maize populations of reduced size
Scientia Agricola, 2002 Inbreeding is a well known phenomenon in living beings and its immediate consequence is the decrease in the expression of quantitative traits, known as inbreeding depression.
Félix Alonso Astete Maldonado +1 more
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Cholesterol stimulates the lytic activity of Adenylate Cyclase Toxin on lipid membranes by promoting toxin oligomerization and formation of pores with a greater effective size. [PDF]
FEBS J, 2021 González Bullón D +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Effective population size – importance in the protection of gene resources
, 2019 The paper describes the effective population size and its importance in the protection of gene resources in Conservation biology. The concept of effective population size has been introduced as a mathematical model, which is enriched with many additional
Trojankiewicz, Magdalena
core +1 more source
Effective Size of Auto-tetraploid Population Under Partial Selfing [PDF]
, 2015 Effective population size is defined as the number of breeding individual in an idealized population that would show the same amount of dispersion of allele frequencies under random genetic drift or the same amount of inbreeding as the population under ...
Muhamad Sabran, Sabran, M. (Muhamad)
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
OR dependence on the effective sample size.
, 2016 OR dependence on the effective sample size.
Irina Arkadievna Bondar (2213725) +4 more
core +1 more source
The full cohort of 512 patients and the nested controlled trial in 93 patients in the Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) study raise doubts about the effective size at present claimed. [PDF]
J Cardiothorac Surg, 2022 Treasure T, Williams NR, Macbeth F.
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source