Results 61 to 70 of about 1,647,342 (298)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The hadronic off-shell width of meson resonances [PDF]
, 2000 Within the resonance chiral effective theory we study the dressed propagators of the spin-1 fields, as arise from a Dyson-Schwinger resummation perturbatively constructed from loop diagrams with absorptive contributions in the s-channel.
Dumm, D. Gomez, Pich, A., Portoles, J.
core +4 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Neutral Evolution as Diffusion in phenotype space: reproduction with mutation but without selection
, 2007 The process of `Evolutionary Diffusion', i.e. reproduction with local mutation but without selection in a biological population, resembles standard Diffusion in many ways.
A. Winter +13 more
core +2 more sources
Quasiparticle Properties in Effective Field Theory [PDF]
, 2002 The quasiparticle concept is an important tool for the description of many-body systems. We study the quasiparticle properties for dilute Fermi systems with short-ranged, repulsive interactions using effective field theory.
Baker +38 more
core +2 more sources
Finite width effects in top quark decays [PDF]
Physics Letters B, 1995 Motivated by evidence that the top quark mass lies near the $bWZ$ threshold, we compute the decay rate for $t\rightarrow bWZ$ in the Standard Model, including the effects of the finite widths of the $W$ and $Z$ bosons. In the limit where the width effects are negligible, our results disagree with previously published calculations.
MAHLON, Gregory, PARKE, Stephen
openaire +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Empowering a helper cluster through data-width aware instruction selection policies [PDF]
, 2006 Narrow values that can be represented by less number of bits than the full machine width occur very frequently in programs. On the other hand, clustering mechanisms enable cost- and performance-effective scaling of processor back-end features.
Ergin, Oguz +3 more
core +1 more source
A case for a complexity-effective, width-partitioned microarchitecture [PDF]
ACM Transactions on Architecture and Code Optimization, 2006 The analysis of program executions reveals that most integer and multimedia applications make heavy use of narrow-width operations, i.e., instructions exclusively using narrow-width operands and producing a narrow-width result. Moreover, this usage is relatively well distributed over the application.
Olivier Rochecouste +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source