Results 111 to 120 of about 978,587 (263)

Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with pseudomonas syringae pv tomato DC3000 [PDF]

, 2015
Transcriptional reprogramming is integral to effective plant defense. Pathogen effectors act transcriptionally and posttranscriptionally to suppress defense responses.
Grant, Murray, Rand, D., de, Torres-Zabala M, Mead, Andrew, Littlejohn, G., Littlejohn, George, Hickman, Richard J., Jenkins, Dafyd J., Wild, D. L., Prusińska, Justyna, Smirnoff, N., Bowden, Laura, Moore, Jonathan D., Truman, W., Steinbrenner, Jens, Lewis, L. A., Jayaraman, S., Baxter, L., Buchanan-Wollaston, Vicky, Hills, Claire E., Jayaraman, Siddharth; id_orcid, Polanski, Krzysztof, Hill, Claire, Hill, C., Hickman, R., Lewis, Laura A., Jenkins, D. J., Jayaraman, Siddharth, Ott, Sascha, Steinbrenner, J., Smirnoff, Nick, De Torres-Zabala, M., Kulasekaran, S., Bowden, L., Ott, S., Hickman, Richard, Lewis, Laura, Beynon, Jim, Prusinska, J., Moore, J., Baxter, Laura, Denby, K., Denby, Katherine J., Denby, Katherine, Grant, M., Rand, D. A., Polanski, K., Truman, William, Penfold, Christopher A., Wild, David L., Moore, Jonathan, Polanskia, Krzysztof, Kulasekaran, Satish, Buchanan-Wollaston, V., de Torres-Zabala, Marta, Rand, David, Penford, C. A., Mead, A., Beynon, J., Penfold, C.A., Jenkins, D.J., Wild, D.L., Lewis, L.A.   +62 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

A splicing checkpoint couples surface and intracellular plant immunity

Phytopathology Research
Plant immunity operates through two interconnected layers. Pattern-triggered immunity (PTI) is initiated by cell-surface pattern-recognition receptors, whereas effector-triggered immunity (ETI) is executed by intracellular nucleotide-binding leucine-rich
Enoch Lok Him Yuen
doaj   +1 more source

Pseudomonas cold shock proteins suppress bacterial effector translocation in Nicotiana benthamiana

Frontiers in Microbiology
IntroductionPlants detect the invasion of microbial pathogens through pathogen-associated molecular patterns (PAMPs). Cold shock proteins (CSPs) are a class of PAMPs specifically recognized by Solanales plants.
Shen Cong, Jun-Zhou Li, Mei-Ran Zhang, Mei-Ran Zhang, Hai-Lei Wei, Wei Zhang   +5 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The role of salicylic acid receptors NPR1 and NPR3/4 in PAMP-triggered immunity and effector-triggered immunity

, 2020
Plants are constantly exposed to different pathogens in their environment and they have evolved complex defense strategies to avoid potential disease.
Radojicic, Ana
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Receptor-like proteins: decision-makers of plant immunity

Phytopathology Research
Receptor-like proteins (RLPs) are crucial pattern-recognition receptors on the surface of plant cells, which are involved in almost all processes of the plant life cycle.
Minrui Cai, Hongqiang Yu, E Sun, Cunwu Zuo   +3 more
doaj   +1 more source

Recent advances in plant immunity: recognition, signaling, response, and evolution

Biologia Plantarum, 2013
Innate immune system is employed by plants to defend against phytopathogenic microbes through specific perception of non-self molecules and subsequent initiation of resistance responses.
S. Hou, C. Zhang, Y. Yang, D. Wu
doaj   +1 more source