Results 101 to 110 of about 853,048 (256)

Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets [PDF]

, 2005
Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (T(CM)), effector memory (T(EM)), and effector memory RA (T(EMRA)) T cells using gene ...
Freeman, Tom, Hasegawa, Hitoshi, Willinger, Tim, Callan, Margaret F C, McMichael, Andrew J   +4 more
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with pseudomonas syringae pv tomato DC3000 [PDF]

, 2015
Transcriptional reprogramming is integral to effective plant defense. Pathogen effectors act transcriptionally and posttranscriptionally to suppress defense responses.
Grant, Murray, Rand, D., de, Torres-Zabala M, Mead, Andrew, Littlejohn, G., Littlejohn, George, Hickman, Richard J., Jenkins, Dafyd J., Wild, D. L., Prusińska, Justyna, Smirnoff, N., Bowden, Laura, Moore, Jonathan D., Truman, W., Steinbrenner, Jens, Lewis, L. A., Jayaraman, S., Baxter, L., Buchanan-Wollaston, Vicky, Hills, Claire E., Jayaraman, Siddharth; id_orcid, Polanski, Krzysztof, Hill, Claire, Hill, C., Hickman, R., Lewis, Laura A., Jenkins, D. J., Jayaraman, Siddharth, Ott, Sascha, Steinbrenner, J., Smirnoff, Nick, De Torres-Zabala, M., Kulasekaran, S., Bowden, L., Ott, S., Hickman, Richard, Lewis, Laura, Beynon, Jim, Prusinska, J., Moore, J., Baxter, Laura, Denby, K., Denby, Katherine J., Denby, Katherine, Grant, M., Rand, D. A., Polanski, K., Truman, William, Penfold, Christopher A., Wild, David L., Moore, Jonathan, Polanskia, Krzysztof, Kulasekaran, Satish, Buchanan-Wollaston, V., de Torres-Zabala, Marta, Rand, David, Penford, C. A., Mead, A., Beynon, J.   +58 more
core   +1 more source

Advances in Fungal Elicitor-Triggered Plant Immunity

, 2022
There is an array of pathogenic fungi in the natural environment of plants, which produce some molecules including pathogen-associated molecular patterns (PAMPs) and effectors during infection.
Jia Guo, Cheng, Yulin, Yulin Cheng, Guo, Jia   +3 more
core   +1 more source

Viral effectors trigger innate immunity across the tree of life

Philosophical Transactions of the Royal Society B: Biological Sciences
Viruses are ubiquitous biological entities that exert immense selective pressures on their hosts, driving the evolution of diverse innate immune mechanisms across all domains of life. While innate immunity has historically been studied in eukaryotes, recent discoveries of bacterial defence systems against phages reveal striking parallels between ...
Kevin Barthes, Francois Rousset, Tanita Wein   +2 more
openaire   +3 more sources

A viral effector blocks the turnover of a plant NLR receptor to trigger a robust immune response

The EMBO Journal
Plant intracellular nucleotide-binding and leucine-rich repeat immune receptors (NLRs) play a key role in activating a strong pathogen defense response. Plant NLR proteins are tightly regulated and accumulate at very low levels in the absence of pathogen
Chunli Wang, Min Zhu, Hao Hong, Jia Li, Chongkun Zuo, Yu Zhang, Yajie Shi, Suyu Liu, Haohua Yu, Yuling Yan, Jing Chen, Lingna Shangguan, Aiping Zhi, Rongzhen Chen, Karen Thulasi Devendrakumar, Xiaorong Tao   +15 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The molecular basis of host specialization in bean pathovars of Pseudomonas syringae [PDF]

, 2012
Biotrophic phytopathogens are typically limited to their adapted host range. In recent decades, investigations have teased apart the general molecular basis of intraspecific variation for innate immunity of plants, typically involving receptor ...
Baltrus, David A., Biswas, Surojit, Vicente, Joana G., Nishimura, Marc T., Holub, E. B., Mukhtar, M. Shahid, Dougherty, Kevin M., Dangl, J. L. (Jeffery L.)   +7 more
core   +1 more source

Variations on a theme: Non-canonical mechanisms of effector-triggered immunity

Current Opinion in Plant Biology
Effector-triggered immunity (ETI) can be defined as immune responses activated upon specific recognition of a pathogen effector protein by its cognate plant immune receptor protein. This classic gene-for-gene model of the interaction of one pathogen effector, also known as an Avirulence (Avr) gene, with one plant immune receptor gene, known as a ...
Hee-Kyung Ahn, Jonathan D.G. Jones, Guanghao Guo   +2 more
openaire   +2 more sources