Results 81 to 90 of about 853,048 (256)

Network properties of robust immunity in plants. [PDF]

PLoS Genetics, 2009
Two modes of plant immunity against biotrophic pathogens, Effector Triggered Immunity (ETI) and Pattern-Triggered Immunity (PTI), are triggered by recognition of pathogen effectors and Microbe-Associated Molecular Patterns (MAMPs), respectively. Although
Kenichi Tsuda, Masanao Sato, Thomas Stoddard, Jane Glazebrook, Fumiaki Katagiri   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces protective immunity against upper genital tract pathologies in mice.

, 2009
Chlamydia trachomatis genome is predicted to encode a type III secretion system consisting of more than 40 open reading frames (ORFs). To test whether these ORFs are expressed and immunogenic during chlamydial infection in humans, we expressed 55 ...
Perdue, Sondra, Yeh, I-Tien, Mabey, David, Xiaoyun Zhang, Bailey, Robin, Joel Baseman, Yeh, I.-Tien, Ping Yu, Jie Wang, Martin Holland, Zhang, Yingqian, I.-Tien Yeh, Fan Chen, Zhong, Guangming, Baseman, Joel, Sondra Perdue, Holland, Martin, Lili Chen, Zhang, Xiaoyun, Guangming Zhong, Wang, Jie, Rochelle Shain, Yingqian Zhang, Chen, Fan, David Mabey, Shain, Rochelle, Chen, Lili, Robin Bailey, Yu, Ping   +28 more
core   +1 more source

The Magnaporthe oryzae effector Avr-PikD suppresses rice immunity by inhibiting an LSD1-like transcriptional activator

Crop Journal
Avirulence effectors (Avrs), encoded by plant pathogens, can be recognized by plants harboring the corresponding resistance proteins, thereby initiating effector-triggered immunity (ETI).
Jiayuan Guo, Yiling Wu, Jianqiang Huang, Kaihui Yu, Meilian Chen, Yijuan Han, Zhenhui Zhong, Guodong Lu, Yonghe Hong, Zonghua Wang, Xiaofeng Chen   +10 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

AvrBsT acetylates Arabidopsis ACIP1, a protein that associates with microtubules and is required for immunity.

PLoS Pathogens, 2014
Bacterial pathogens of plant and animals share a homologous group of virulence factors, referred to as the YopJ effector family, which are translocated by the type III secretion (T3S) system into host cells during infection.
Mi Sun Cheong, Angela Kirik, Jung-Gun Kim, Kenneth Frame, Viktor Kirik, Mary Beth Mudgett   +5 more
doaj   +1 more source

Modular mechanisms of immune priming and growth inhibition mediated by plant effector-triggered immunity [PDF]

Cell Reports
Summary Excessive activation of effector-triggered immunity (ETI) in plants inhibits plant growth and activates cell death. ETI mediated by intracellular Toll/Interleukin-1 receptor/Resistance protein (TIR) nucleotide-binding leucine-rich-repeat receptors (NLRs) involves two partially redundant signalling nodes in Arabidopsis, EDS1-PAD4-
Chhillar H, Yeh P, Nguyen HH, Jones JD, Ding P.   +4 more
europepmc   +4 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Unlocking Nature's Defense: Plant Pattern Recognition Receptors as Guardians Against Pathogenic Threats

Molecular Plant-Microbe Interactions
Embedded in the plasma membrane of plant cells, receptor kinases (RKs) and receptor proteins (RPs) act as key sentinels, responsible for detecting potential pathogenic invaders.
Chao Zhang, Yingpeng Xie, Ping He, Libo Shan   +3 more
doaj   +1 more source

A Novel Effector Gene SCRE2 Contributes to Full Virulence of Ustilaginoidea virens to Rice

Frontiers in Microbiology, 2019
Ustilaginoidea virens, the causal agent of rice false smut (RFS), has become one of the most devastating rice pathogens worldwide. As a group of essential virulence factors, the effectors in the filamentous fungus might play central roles in the ...
Anfei Fang, Anfei Fang, Han Gao, Nan Zhang, Xinhang Zheng, Shanshan Qiu, Yuejiao Li, Shuang Zhou, Fuhao Cui, Wenxian Sun, Wenxian Sun   +10 more
doaj   +1 more source