Results 61 to 70 of about 853,048 (256)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The MAP4 kinase NbM4K3 regulates immune responses in Nicotiana benthamiana

Phytopathology Research
The mitogen-activated protein kinase kinase kinase kinase (M4K) family is evolutionarily conserved across plants and animals. In Arabidopsis, the protein kinase SIK1, an M4K member, is known to positively modulate reactive oxygen species (ROS) production
Shuangxi Zhang, Haijuan Li, Meixiang Zhang, Yuyan An   +3 more
doaj   +1 more source

What are the Top 10 Unanswered Questions in Molecular Plant-Microbe Interactions?

Molecular Plant-Microbe Interactions, 2020
This article is part of the Top 10 Unanswered Questions in MPMI invited review series.The past few decades have seen major discoveries in the field of molecular plant-microbe interactions.
Jeanne M. Harris, Peter Balint-Kurti, Jacqueline C. Bede, Brad Day, Scott Gold, Erica M. Goss, Laura J. Grenville-Briggs, Kathryn M. Jones, Aiming Wang, Yuanchao Wang, Raka M. Mitra, Kee Hoon Sohn, Maria Elena Alvarez   +12 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The interplay between a Phytophthora RXLR effector and an Arabidopsis lectin receptor kinase [PDF]

, 2010
Phytophthora infestans – the causal agent of potato late blight – secretes a plethora of effector proteins to facilitate plant infection. The central subject of this thesis is ipiO, one of the first cloned Phytophthora genes with a putative function in ...
Bouwmeester, K.
core  

Three LysM effectors of Zymoseptoria tritici collectively disarm chitin‐triggered plant immunity [PDF]

, 2021
Chitin is a major structural component of fungal cell walls and acts as a microbe‐associated molecular pattern (MAMP) that, on recognition by a plant host, triggers the activation of immune responses.
Rodriguez-Moreno, Luis, Chen, Hongxin, Bart P. H. J. Thomma, van den Berg, Grardy C.M., Mesters, J. R., Rudd, Jason J., Thomma, Bart P.H.J., Rudd, Jason, Craig I. MacKenzie, Mesters, Jeroen R., Jeroen R. Mesters, Thomma, Bart, Tian, Hui, Jason J. Rudd, Van den Berg, Grardy, MacKenzie, Craig I., Hui Tian, Tian, H., Van den Berg, G. C. M., MacKenzie, Craig, Grardy C. M. van den Berg, Thomma, B. P. H. J., Mesters, Jeroen, Rudd, J. J., Luis Rodriguez‐Moreno, MacKenzie, C. I., Rodríguez-Moreno, Luis Gabriel, Chen, H., Rodriguez-Moreno, L., Hongxin Chen   +29 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

The Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cells [PDF]

, 2012
Phytopathogenic oomycetes, such as Phytophthora infestans, secrete an arsenal of effector proteins that modulate plant innate immunity to enable infection. We describe CRN8, a host-translocated effector of P. infestans that has kinase activity in planta.
Cakir, Cahid, Tolga O Bozkurt, Sebastian Schornack, Cahid Cakir, Mireille van Damme, Cahid Cakir (142118), Bozkurt, Tolga O, Kamoun, S., Kamoun, Sophien, van Damme, M., Jones, A.M.E., Sklenar, Jan, Sophien Kamoun (6132), Cakir, C., Schornack, S., Schornack, Sebastian, van Damme, Mireille, Jan Sklenar (142122), Jones, Alexandra ME, Jones, Alexandra M., Mireille van Damme (142110), Tolga O. Bozkurt (142114), Bozkurt, Tolga O., Sophien Kamoun, Bozkurt, T.O., Sklenar, J., Alexandra M. E. Jones (50010), Alexandra M E Jones, Damme, M., van, Sebastian Schornack (142120), Jan Sklenar   +30 more
core   +1 more source