Results 71 to 80 of about 978,587 (263)

Image_1_Suppression of HopZ Effector-Triggered Plant Immunity in a Natural Pathosystem.PDF

, 2018
Many type III-secreted effectors suppress plant defenses, but can also activate effector-triggered immunity (ETI) in resistant backgrounds. ETI suppression has been shown for a number of type III effectors (T3Es) and ETI-suppressing effectors are ...
Inmaculada Ortiz-Martín (168166), Javier Rueda-Blanco (5627996), Adela Zumaquero (168161), Gonzalo Ruiz-Aldea (5628002), Carlos M. Guevara (5627999), Alberto P. Macho (168158), José S. Rufián (168168), Javier Ruiz-Albert (5628005), Ainhoa Lucía (5627993), Carmen R. Beuzón (168170)   +9 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Table_2_Suppression of HopZ Effector-Triggered Plant Immunity in a Natural Pathosystem.DOCX

, 2018
Many type III-secreted effectors suppress plant defenses, but can also activate effector-triggered immunity (ETI) in resistant backgrounds. ETI suppression has been shown for a number of type III effectors (T3Es) and ETI-suppressing effectors are ...
Inmaculada Ortiz-Martín (168166), Javier Rueda-Blanco (5627996), Adela Zumaquero (168161), Gonzalo Ruiz-Aldea (5628002), Carlos M. Guevara (5627999), Alberto P. Macho (168158), José S. Rufián (168168), Javier Ruiz-Albert (5628005), Ainhoa Lucía (5627993), Carmen R. Beuzón (168170)   +9 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Pathogen effectors and their implications for crop genetic improvement

Plant Stress
Plants are continuously affected by a wide range of pathogens, including fungi, bacteria, and viruses, posing serious threats to global food security and economic sustainability.
Frank Kalungi, Saira Ibrahim, Peter Nkachukwu Chukwurah, Eric Kisaakye Kyambadde, Felix Tuyisabe, Abubakar Sadik Mustafa, Valentine Otang Ntui   +6 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The bacterial type III-secreted protein AvrRps4 is a bipartite effector. [PDF]

PLoS Pathogens, 2018
Bacterial effector proteins secreted into host plant cells manipulate those cells to the benefit of the pathogen, but effector-triggered immunity (ETI) occurs when effectors are recognized by host resistance proteins.
Morgan K Halane, Sang Hee Kim, Benjamin J Spears, Christopher M Garner, Conner J Rogan, Elizabeth C Okafor, Jianbin Su, Saikat Bhattacharjee, Walter Gassmann   +8 more
doaj   +1 more source

Host Inhibition of a Bacterial Virulence Effector Triggers Immunity to Infection

Science, 2009
Infections and Defense Bacteria secrete effectors to suppress immunity in plant and animal hosts resulting in an evolutionary arms race between bacteria and their eukaryotic hosts. One important aspect of plant immunity against bacteria is based on disease resistance protein complexes, which recognize specific ...
Ntoukakis, Vardis, Mucyn, Tatiana, Gimenez-Ibanez, Selena, Chapman, Helen C, Gutierrez, Jose R, Balmuth, Alexi L, Jones, Alexandra, Rathjen, John   +7 more
openaire   +3 more sources

Model of C. destructans infection in the effector-triggered immunity, phytohormones, reactive oxygen species and ginsenoside biosynthetic pathway.

, 2016
Model of C. destructans infection in the effector-triggered immunity, phytohormones, reactive oxygen species and ginsenoside biosynthetic pathway.
Yuan Gao (159945), Xiaoli He (139890), Tianwei Shao (2147323), Yong Li (15029), Bin Wu (138543), Zi Wang (324031), Jianhe Wei (2147320), Wanlong Ding (2147314), Qiliang Long (2147317)   +8 more
core   +1 more source