Results 71 to 80 of about 853,048 (256)

Pathogen effectors and their implications for crop genetic improvement

Plant Stress
Plants are continuously affected by a wide range of pathogens, including fungi, bacteria, and viruses, posing serious threats to global food security and economic sustainability.
Frank Kalungi, Saira Ibrahim, Peter Nkachukwu Chukwurah, Eric Kisaakye Kyambadde, Felix Tuyisabe, Abubakar Sadik Mustafa, Valentine Otang Ntui   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Plant Immunity against Tobamoviruses

Viruses
Tobamoviruses are a group of plant viruses that pose a significant threat to agricultural crops worldwide. In this review, we focus on plant immunity against tobamoviruses, including pattern-triggered immunity (PTI), effector-triggered immunity (ETI ...
Xiyin Zheng, Yiqing Li, Yule Liu
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Host Inhibition of a Bacterial Virulence Effector Triggers Immunity to Infection

Science, 2009
Infections and Defense Bacteria secrete effectors to suppress immunity in plant and animal hosts resulting in an evolutionary arms race between bacteria and their eukaryotic hosts. One important aspect of plant immunity against bacteria is based on disease resistance protein complexes, which recognize specific bacterial effectors
Ntoukakis, Vardis, Mucyn, Tatiana, Gimenez-Ibanez, Selena, Chapman, Helen C, Gutierrez, Jose R, Balmuth, Alexi L, Jones, Alexandra, Rathjen, John   +7 more
openaire   +3 more sources

The bacterial type III-secreted protein AvrRps4 is a bipartite effector. [PDF]

PLoS Pathogens, 2018
Bacterial effector proteins secreted into host plant cells manipulate those cells to the benefit of the pathogen, but effector-triggered immunity (ETI) occurs when effectors are recognized by host resistance proteins.
Morgan K Halane, Sang Hee Kim, Benjamin J Spears, Christopher M Garner, Conner J Rogan, Elizabeth C Okafor, Jianbin Su, Saikat Bhattacharjee, Walter Gassmann   +8 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Characterisation of Mycobacterium tuberculosis specific T cell immunity with HLA class II tetramers [PDF]

, 2014
Includes bibliographical references.Tuberculosis (TB) remains a global health burden, with an estimated 1.3 million people dying from the disease in 2012. Protective immunity against TB is thought to depend on specific T cells.
Dintwe, One Bridget
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source