Results 91 to 100 of about 978,587 (263)

AvrBsT acetylates Arabidopsis ACIP1, a protein that associates with microtubules and is required for immunity.

PLoS Pathogens, 2014
Bacterial pathogens of plant and animals share a homologous group of virulence factors, referred to as the YopJ effector family, which are translocated by the type III secretion (T3S) system into host cells during infection.
Mi Sun Cheong, Angela Kirik, Jung-Gun Kim, Kenneth Frame, Viktor Kirik, Mary Beth Mudgett   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Unlocking Nature's Defense: Plant Pattern Recognition Receptors as Guardians Against Pathogenic Threats

Molecular Plant-Microbe Interactions
Embedded in the plasma membrane of plant cells, receptor kinases (RKs) and receptor proteins (RPs) act as key sentinels, responsible for detecting potential pathogenic invaders.
Chao Zhang, Yingpeng Xie, Ping He, Libo Shan   +3 more
doaj   +1 more source

A Novel Effector Gene SCRE2 Contributes to Full Virulence of Ustilaginoidea virens to Rice

Frontiers in Microbiology, 2019
Ustilaginoidea virens, the causal agent of rice false smut (RFS), has become one of the most devastating rice pathogens worldwide. As a group of essential virulence factors, the effectors in the filamentous fungus might play central roles in the ...
Anfei Fang, Anfei Fang, Han Gao, Nan Zhang, Xinhang Zheng, Shanshan Qiu, Yuejiao Li, Shuang Zhou, Fuhao Cui, Wenxian Sun, Wenxian Sun   +10 more
doaj   +1 more source

Regulation and Functions of ROP GTPases in Plant–Microbe Interactions

Cells, 2020
Rho proteins of plants (ROPs) form a specific clade of Rho GTPases, which are involved in either plant immunity or susceptibility to diseases. They are intensively studied in grass host plants, in which ROPs are signaling hubs downstream of both cell ...
Stefan Engelhardt, Adriana Trutzenberg, Ralph Hückelhoven   +2 more
doaj   +1 more source

Modular mechanisms of immune priming and growth inhibition mediated by plant effector-triggered immunity [PDF]

Cell Reports
Summary Excessive activation of effector-triggered immunity (ETI) in plants inhibits plant growth and activates cell death. ETI mediated by intracellular Toll/Interleukin-1 receptor/Resistance protein (TIR) nucleotide-binding leucine-rich-repeat receptors (NLRs) involves two partially redundant signalling nodes in Arabidopsis, EDS1-PAD4-
Chhillar H, Yeh P, Nguyen HH, Jones JD, Ding P.   +4 more
europepmc   +4 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Host-MediatedS-Nitrosylation Disarms the Bacterial Effector HopAI1 to Reestablish Immunity

, 2017
Pathogens deliver effectors into plant cells to suppress immunity-related signaling. However, effector recognition by the host elicits a hypersensitive response (HR) that overcomes the inhibition of host signaling networks, restoring disease resistance ...
Zahra Imanifard, Vandelle, Elodie, Bellin, Diana, Tengfang Ling, Massimo Delledonne, Ling, Tengfang, Elodie Vandelle, Diana Bellin, Delledonne, Massimo, Imanifard, Zahra   +9 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Quantitative phosphoproteomic analysis reveals common regulatory mechanisms between effector- and PAMP-triggered immunity in plants [PDF]

, 2018
Plant immunity consists of two arms: pathogen‐associated molecular pattern (PAMP)‐triggered immunity (PTI), induced by surface‐localized receptors, and effector‐triggered immunity (ETI), induced by intracellular receptors.
Shirasu, Ken, Sklenar, Jan; https://orcid.org/, Antonio Molina, Torres, Miguel-Angel; https://orcid.org/, Thomas W. H. Liebrand, Coaker, Gitta; https://orcid.org/, Derbyshire, Paul, Menke, Frank, Kadota, Yasuhiro; https://orcid.org/, Yasuhiro Kadota, Zipfel, Cyril, Coaker, Gitta, Menke, Frank L H; https://orcid.org/, Miguel‐Angel Torres, Liebrand, Thomas W H; https://orcid.org/, Frank L. H. Menke, Gitta Coaker, Ken Shirasu, Goto, Yukihisa, Sklenar, Jan, Menke, Franciscus, Liebrand, Thomas WH, Cyril Zipfel, Kadota, Yasuhiro, Liebrand, Thomas W. H., Torres, Miguel Ángel, Goto, Yukihisa; https://orcid.org/, Zipfel, Cyril; https://orcid.org/, Torres, Miguel-Angel, Molina, Antonio, Derbyshire, Paul; https://orcid.org/, Yukihisa Goto, Shirasu, Ken; https://orcid.org/, Liebrand, Thomas, Paul Derbyshire, Molina, Antonio; https://orcid.org/, Menke, Frank LH, Torres, Miguel‐Angel, Jan Sklenar, Menke, Frank L. H.   +39 more
core   +1 more source