Effector-triggered post-translational modifications and their role in suppression of plant immunity
Plant-pathogen interactions feature complex signalling exchanges between host and microbes that ultimately determine association outcomes. Plants deploy Pattern Recognition Receptors (PRRs) to perceive Pathogen Associated Molecular Patterns (PAMPs ...
Andrew James Mark Howden, Edgar eHuitema
doaj +1 more source
A working model for cytoplasmic assembly of H/ACA snoRNPs
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
Bacterial effector-involved temporal and spatial regulation by hijack of the host ubiquitin pathway
Ubiquitination is one of the most conserved post-translational modifications of proteins, and is involved in essential eukaryotic cellular processes.
Tomoko eKubori +2 more
doaj +1 more source
Lytic polysaccharide monooxygenases (LPMOs) are widely distributed in fungi, and catalyze the oxidative degradation of polysaccharides such as cellulose.
Erik Breslmayr +6 more
doaj +1 more source
Improved prediction of fungal effector proteins from secretomes with EffectorP 2.0
Plant-pathogenic fungi secrete effector proteins to facilitate infection. We describe extensive improvements to EffectorP, the first machine learning classifier for fungal effector prediction. EffectorP 2.0 is now trained on a larger set of effectors and
Jana Sperschneider +4 more
semanticscholar +1 more source
Novel and unscrutinized immune entities of the zebrafish gut
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
Effector Pt9226 from Puccinia triticina Presents a Virulence Role in Wheat Line TcLr15
Effectors are considered to be virulence factors secreted by pathogens, which play an important role during host-pathogen interactions. In this study, the candidate effector Pt9226 was cloned from genomic DNA of Puccinia triticina (Pt) pathotype THTT ...
Bingxue Wang +8 more
doaj +1 more source
Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life
Antibodies and Fc-fusion antibody-like proteins have become successful biologics developed for cancer treatment, passive immunity against infection, addiction, and autoimmune diseases.
K. Saunders
semanticscholar +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
VopX, a novel Vibrio cholerae T3SS effector, modulates host actin dynamics
Pathogenic Vibrio cholerae strains cause cholera using different mechanisms. O1 and O139 serogroup strains use the toxin-co-regulated pilus (TCP) and cholera toxin (CT) for intestinal colonization and to promote secretory diarrhea, while non-O1/non-O139 ...
Megan Ulbrich +5 more
doaj +1 more source

