Results 51 to 60 of about 13,977,700 (260)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Border Control: Manipulation of the Host–Pathogen Interface by Perihaustorial Oomycete Effectors

Molecular Plant-Microbe Interactions
Filamentous plant pathogens, including fungi and oomycetes, cause some of the most devastating plant diseases. These organisms serve as ideal models for understanding the intricate molecular interplay between plants and the invading pathogens ...
Freddie J. King, Enoch Lok Him Yuen, Tolga O. Bozkurt   +2 more
doaj   +1 more source

A T4SS Effector Targets Host Cell Alpha-Enolase Contributing to Brucella abortus Intracellular Lifestyle

Frontiers in Cellular and Infection Microbiology, 2016
Brucella abortus, the causative agent of bovine brucellosis, invades and replicates within cells inside a membrane-bound compartment known as the Brucella containing vacuole (BCV). After trafficking along the endocytic and secretory pathways, BCVs mature
Maria Inés Marchesini, Susana María Morrone Seijo, Francisco Fernando Guaimas, Diego J. Comerci, Diego J. Comerci   +4 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Comparative secretome analysis unveils species-specific virulence factors in Elsinoe perseae, the causative agent of the scab disease of avocado (Persea americana)

AIMS Microbiology
The scab disease, caused by Elsinoe perseae, poses a significant risk to avocado (Persea americana) production in countries with warm and humid climates.
Biju Vadakkemukadiyil Chellappan
doaj   +1 more source

A complete toolset for the study of Ustilago bromivora and Brachypodium sp. as a fungal-temperate grass pathosystem

eLife, 2016
Due to their economic relevance, the study of plant pathogen interactions is of importance. However, elucidating these interactions and their underlying molecular mechanisms remains challenging since both host and pathogen need to be fully genetically ...
Franziska Rabe, Jason Bosch, Alexandra Stirnberg, Tilo Guse, Lisa Bauer, Denise Seitner, Fernando A Rabanal, Angelika Czedik-Eysenberg, Simon Uhse, Janos Bindics, Bianca Genenncher, Fernando Navarrete, Ronny Kellner, Heinz Ekker, Jochen Kumlehn, John P Vogel, Sean P Gordon, Thierry C Marcel, Martin Münsterkötter, Mathias C Walter, Christian MK Sieber, Gertrud Mannhaupt, Ulrich Güldener, Regine Kahmann, Armin Djamei   +24 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Recognition of a Fungal Effector Potentiates Pathogen‐Associated Molecular Pattern‐Triggered Immunity in Cotton

Advanced Science
Plants are equipped with multi‐layered immune systems that recognize pathogen‐derived elicitors to activate immunity. Verticillium dahliae is a soil‐borne fungus that infects a broad range of plants and causes devastating wilt disease.
Lifan Sun, Xiangguo Li, Jiajie Zhong, Yu Wang, Baiyang Li, Ziqin Ye, Jie Zhang   +6 more
doaj   +1 more source

Large-Scale Identification and Characterization of Heterodera avenae Putative Effectors Suppressing or Inducing Cell Death in Nicotiana benthamiana

Frontiers in Plant Science, 2018
Heterodera avenae is one of the most important plant pathogens and causes vast losses in cereal crops. As a sedentary endoparasitic nematode, H. avenae secretes effectors that modify plant defenses and promote its biotrophic infection of its hosts ...
Changlong Chen, Changlong Chen, Yongpan Chen, Heng Jian, Dan Yang, Yiran Dai, Lingling Pan, Lingling Pan, Fengwei Shi, Fengwei Shi, Shanshan Yang, Qian Liu   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source