Results 71 to 80 of about 18,981,148 (397)

Border Control: Manipulation of the Host–Pathogen Interface by Perihaustorial Oomycete Effectors

Molecular Plant-Microbe Interactions
Filamentous plant pathogens, including fungi and oomycetes, cause some of the most devastating plant diseases. These organisms serve as ideal models for understanding the intricate molecular interplay between plants and the invading pathogens ...
Freddie J. King, Enoch Lok Him Yuen, Tolga O. Bozkurt   +2 more
doaj   +1 more source

A complete toolset for the study of Ustilago bromivora and Brachypodium sp. as a fungal-temperate grass pathosystem

eLife, 2016
Due to their economic relevance, the study of plant pathogen interactions is of importance. However, elucidating these interactions and their underlying molecular mechanisms remains challenging since both host and pathogen need to be fully genetically ...
Franziska Rabe, Jason Bosch, Alexandra Stirnberg, Tilo Guse, Lisa Bauer, Denise Seitner, Fernando A Rabanal, Angelika Czedik-Eysenberg, Simon Uhse, Janos Bindics, Bianca Genenncher, Fernando Navarrete, Ronny Kellner, Heinz Ekker, Jochen Kumlehn, John P Vogel, Sean P Gordon, Thierry C Marcel, Martin Münsterkötter, Mathias C Walter, Christian MK Sieber, Gertrud Mannhaupt, Ulrich Güldener, Regine Kahmann, Armin Djamei   +24 more
doaj   +1 more source

Analysis of Binding Site Hot Spots on the Surface of Ras GTPase [PDF]

, 2011
We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers.
Buhrman, Greg, Kearney, Bradley M., Kovrigina, Elizaveta A., Kovriguine, Evgueni, Kozakov, Dima, Mattos, Carla, Napoleon, Raeanne, O\u27Connor, Casey, Vajda, Sandor, Zerbe, Brandon   +9 more
core   +2 more sources

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Comparative secretome analysis unveils species-specific virulence factors in Elsinoe perseae, the causative agent of the scab disease of avocado (Persea americana)

AIMS Microbiology
The scab disease, caused by Elsinoe perseae, poses a significant risk to avocado (Persea americana) production in countries with warm and humid climates.
Biju Vadakkemukadiyil Chellappan
doaj   +1 more source

Large-Scale Identification and Characterization of Heterodera avenae Putative Effectors Suppressing or Inducing Cell Death in Nicotiana benthamiana

Frontiers in Plant Science, 2018
Heterodera avenae is one of the most important plant pathogens and causes vast losses in cereal crops. As a sedentary endoparasitic nematode, H. avenae secretes effectors that modify plant defenses and promote its biotrophic infection of its hosts ...
Changlong Chen, Changlong Chen, Yongpan Chen, Heng Jian, Dan Yang, Yiran Dai, Lingling Pan, Lingling Pan, Fengwei Shi, Fengwei Shi, Shanshan Yang, Qian Liu   +11 more
doaj   +1 more source

Divergent roles of CprK paralogues from Desulfitobacterium hafniense in activating gene expression [PDF]

, 2008
Gene duplication and horizontal gene transfer play an important role in the evolution of prokaryotic genomes. We have investigated the role of three CprK paralogues from the cAMP receptor protein-fumarate and nitrate reduction regulator (CRP-FNR) family ...
Gabor, K., Oost, J., van der, Sene, K.H., Smidt, H., Vos, W.M., de   +4 more
core   +2 more sources

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Recognition of a Fungal Effector Potentiates Pathogen‐Associated Molecular Pattern‐Triggered Immunity in Cotton

Advanced Science
Plants are equipped with multi‐layered immune systems that recognize pathogen‐derived elicitors to activate immunity. Verticillium dahliae is a soil‐borne fungus that infects a broad range of plants and causes devastating wilt disease.
Lifan Sun, Xiangguo Li, Jiajie Zhong, Yu Wang, Baiyang Li, Ziqin Ye, Jie Zhang   +6 more
doaj   +1 more source

Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]

, 2016
Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E, Cruz Cervera, E, Diro, E, Getahun, M, Hailu, A, Kropf, P, Lemma, M, Melkamu, R, Mengesha, B, Mesfin, G, Modolell, M, Muller, I, Munder, M, Skhedy, Z, Tajebe, F, Takele, Y, Van der Auwera, G, Yardley, V, Yeshanew, A, Yizengaw, E   +19 more
core   +3 more sources