Results 271 to 280 of about 19,421,951 (301)

Memory CD4 T Cells Emerge From Effector T-Cell Progenitors

Nature, 2008
A hallmark of adaptive immunity is the generation of memory T cells that confer long-lived, antigen-specific protection against repeat challenges by pathogens. Understanding the mechanisms by which memory T cells arise is important for rational vaccination strategies and improved therapeutic interventions for chronic infections and autoimmune disorders.
Allan J Zajac, Casey T. Weaver, Laurie E Harrington   +2 more
exaly   +3 more sources

Activation of naive, memory and effector T cells

Current Opinion in Immunology, 1994
An increased understanding of the types of T-cell subsets that exist in vivo, their relationships to one another, and how to identify and isolate them or effect their generation, has led to a comprehensive view of the antigen-presenting cells (APCs) which may be active and regulatory during the course of an immune response.
openaire   +2 more sources

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

Annual Review of Immunology, 2004
The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (T CM ) and effector memory (T
Antonio Lanzavecchia, Federica Sallusto, Jens Geginat   +2 more
exaly   +3 more sources

T Cell Responses to Influenza Virus Infection: Effector and Memory Cells

Viral Immunology, 2004
New approaches to visualizing antigen-specific primary responses to influenza and the development of memory subsets in distinct sites suggest that both CD4 and CD8 T cells play complex roles in primary viral clearance and have the potential to contribute to protection from secondary infection.
Susan L, Swain, Richard W, Dutton, David L, Woodland   +2 more
openaire   +2 more sources

Distinct regulation of effector and memory T‐cell differentiation

Immunology & Cell Biology, 2008
Three major subsets of antigen‐experienced T cells have been identified based on surface markers and distinct functional properties: short‐lived effector T cells, central memory T cells and effector memory T cells. The precise relationship among these subsets and their mode of differentiation are still controversial.
openaire   +2 more sources

Intrinsic and extrinsic control of effector T cell survival and memory T cell development

Immunologic Research, 2008
Following infection or vaccination T cells expand exponentially and differentiate into effector T cells in order to control infection and coordinate the multiple effector arms of the immune system. Soon after this expansion, the majority of antigen-specific T cells die to reattain homeostasis and a small pool of memory T cells forms to provide long ...
Timothy W, Hand, Susan M, Kaech
openaire   +2 more sources

Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells

Science, 2000
The immune response is initiated in organized lymphoid tissues where antigen-loaded dendritic cells (DCs) encounter antigen-specific T cells. DCs function as packets of information that must be decoded by the T cell before an appropriate immune response can be mounted.
A, Lanzavecchia, F, Sallusto
openaire   +2 more sources

Effector Memory CD8⁺ T Cells Are Resistant to Apoptosis

Annals of the New York Academy of Sciences, 2007
Abstract:  Based upon their migrating properties and effector functions, CD8+ T cells have been further classified into central memory (TCM) and two types of effector memory (TEM and TEMRA) cells. These memory cells display distinct replicative characteristics.
Sudhir, Gupta, Sastry, Gollapudi
openaire   +2 more sources

Early effector T helper cells are precursors to both terminal effectors and memory T cells (P1207)

The Journal of Immunology, 2013
Abstract Effector memory CD4+ T cells (Tem) are important for protection from many chronic infections, but their development is poorly understood. While IFN-γ+ effector T cells (Teff) can survive into the memory phase in infection, it is not clear if mature Teff generate Tem, or if memory T cells diverge from Teff early after activation,
Michael Opata, Victor Carpio, Joshua Obiero, Brian Dillon, Robin Stephens   +4 more
openaire   +1 more source

The role and therapeutic strategies for tissue‐resident memory T cells, central memory T cells, and effector memory T cells in psoriasis

Immunology
AbstractPsoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis
Guoshu Deng, Yulin Zhang, Jiankun Song, Ying Zhang, Qi Zheng, Yue Luo, Xiaoya Fei, Yang Yang, Le Kuai, Bin Li, Ying Luo   +10 more
openaire   +2 more sources