Results 281 to 290 of about 19,421,951 (301)

Mucosal effector memory T cells: the other side of the coin

Cellular and Molecular Life Sciences, 2005
Immunological memory allows for rapid and effective protective immunity to previously encountered pathogens. New insights in understanding specific memory differentiation and function have now indicated that in addition to providing enhanced immunity, an important purpose of immunological memory is to provide immediate protection at all sites of the ...
H, Cheroutre, L, Madakamutil
openaire   +2 more sources

Effector memory T‑cells in the pathogenesis of ANCA-associated vasculitides

Zeitschrift für Rheumatologie, 2016
Patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) have an expansion of effector memory T‑cells in peripheral blood. The enlarged effector memory cell population contains distinct cell subsets, including T‑helper type 1 (Th1) CD4+ T‑cells lacking co-stimulatory CD28 expression and Th17 cells in granulomatosis ...
A, Kerstein, A, Müller, D, Kabelitz, P, Lamprecht   +3 more
openaire   +2 more sources

Accumulation of Effector Memory CD8 ⁺ T Cells in Nasal Polyps

American Journal of Rhinology & Allergy, 2013
Background T lymphocytes are prevalent in sinus mucosa and are implicated in chronic rhinosinusitis (CRS) pathogenesis. However, the major T-cell subpopulations, helper (CD4 + ) and cytotoxic (CD8 ...
Pant, Harshita, Hughes, Amy, Miljkovic, Dijana, Schembri, Mark, Wormald, Peter, Macardle, Peta, Grose, Randall, Zola, Heddy, Krumbiegel, Doreen   +8 more
openaire   +4 more sources

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

Nature Immunology, 2005
Two seemingly unrelated hallmarks of memory CD8(+) T cells are cytokine-driven proliferative renewal after pathogen clearance and a latent effector program in anticipation of rechallenge. Memory CD8(+) T cells and natural killer cells share cytotoxic potential and dependence on the growth factor interleukin 15.
Andrew M, Intlekofer, Naofumi, Takemoto, E John, Wherry, Sarah A, Longworth, John T, Northrup, Vikram R, Palanivel, Alan C, Mullen, Christopher R, Gasink, Susan M, Kaech, Joseph D, Miller, Laurent, Gapin, Kenneth, Ryan, Andreas P, Russ, Tullia, Lindsten, Jordan S, Orange, Ananda W, Goldrath, Rafi, Ahmed, Steven L, Reiner   +17 more
openaire   +2 more sources

Cytotoxic T Cell Effector and Memory Function in Viral Immunity

1996
The first evidence that virus-specific CD8+ cytotoxic T lymphocytes (CTLs) are primary effectors in vivo came shortly after the discovery of major histo- compatibility complex (MHC)-restricted CD8+ CTL activity (Zinkernagel and Doherty 1974). Adoptive transfer of immune spleen cells from mice of MHC type A into A or (AxB) F1, but not B, virus-infected ...
openaire   +2 more sources

Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T Cells

Immunological Reviews, 1993
Zinkernagel, Rolf M., Moskophidis, Demetrius, Kündig, Thomas, Oehen, Stephan, Pircher, Hanspeter, Hengartner, Hans   +5 more
openaire   +4 more sources

Canonical BAF Complex Activity Shapes the Enhancer Landscape That Licenses CD8+ T Cell Effector and Memory Fates

Immunity, 2023
Dan Chen
exaly  

Central Memory CD8+ T Cells Derive From Stem-Like Tcf7hi Effector Cells in the Absence of Cytotoxic Differentiation

Immunity, 2020
Mauro Delorenzi, Roeltje Maas, Silvia A Fuertes Marraco   +2 more
exaly  

Regulatory T cells limit effector but not memory T cell responses to vaccination.

2009
Chronically infected HBV and HCV patients develop regulatory T cells (Treg) that appear to prevent functional cytotoxic T cell responses. The hope that these patients could benefit from therapeutic vaccination is based on the observation that viral clearance during acute infection is correlated with a strong and multispecific T cell response.
Gasteiger, G., Kastenmüller, W., Stross, L., Sparwasser, T., Busch, D.H., Drexler, I.   +5 more
openaire   +1 more source

Chemokine Receptor CXCR3 Facilitates CD8+ T Cell Differentiation Into Short-Lived Effector Cells Leading to Memory Degeneration

Journal of Experimental Medicine, 2011
Jun Abe, Satoshi Ueha, Kei Sugihara
exaly