Results 51 to 60 of about 2,070,236 (251)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The interplay between a Phytophthora RXLR effector and an Arabidopsis lectin receptor kinase [PDF]

, 2010
Phytophthora infestans – the causal agent of potato late blight – secretes a plethora of effector proteins to facilitate plant infection. The central subject of this thesis is ipiO, one of the first cloned Phytophthora genes with a putative function in ...
Bouwmeester, K.
core  

Identification and distribution of new candidate T6SS effectors encoded in Salmonella Pathogenicity Island 6

Frontiers in Microbiology, 2023
The type VI secretion system (T6SS) is a contact-dependent contractile multiprotein apparatus widely distributed in Gram-negative bacteria. These systems can deliver different effector proteins into target bacterial and/or eukaryotic cells, contributing ...
Carlos J. Blondel, Fernando A. Amaya, Paloma Bustamante, Carlos A. Santiviago, David Pezoa, David Pezoa   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A translocated effector required for bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors [PDF]

, 2013
Numerous bacterial pathogens secrete multiple effectors to modulate host cellular functions. These effectors may interfere with each other to efficiently control the infection process.
Okujava, Rusudan, Dehio, Christoph, Polus, F, Guye, Patrick, Muriel Vayssier-Taussat, Rusudan Okujava, Florine Polus (580547), Cornelia Halin (574950), Halin, Cornelia, Patrick Guye, Cornelia Halin, Polus, Florine, Christoph Dehio, Okujava, R, Guye, P, Florine Polus, Halin, C, Vayssier-Taussat, M, Vayssier-Taussat, Muriel, Vayssier Taussat, Muriel, Muriel Vayssier-Taussat (247536), Claudia Mistl (580546), Yun-Yueh Lu (182156), Christoph Dehio (200951), Yun-Yueh Lu, Rolink, Antonius G., Antonius G. Rolink (268388), Antonius G Rolink, Lu, Y, Mistl, C, Dehio, C, Lu, Yun-Yueh, Mistl, Claudia, Rolink, AG, Rusudan Okujava (580545), Patrick Guye (200949), Claudia Mistl   +36 more
core   +2 more sources

Detection and amplification of LysM effector genes in F. oxysporum f. sp. lycopersici

یافته‌های نوین در علوم زیستی, 2016
During the infection- while the xylem is colonized by the F. oxysporum f. sp. Lycopersici (Fol)- several effector proteins have been secreted into the xylem that suppress the plant’s defense response and enable parasitic colonization. So far, 14 effector
Farhad Shokouhifar, Elahe Rabiei-Motlagh, Nahid Abbaspour, Sahba Toosi   +3 more
doaj  

Suppression or Activation of Immune Responses by Predicted Secreted Proteins of the Soybean Rust Pathogen Phakopsora pachyrhizi

Molecular Plant-Microbe Interactions, 2018
Rust fungi, such as the soybean rust pathogen Phakopsora pachyrhizi, are major threats to crop production. They form specialized haustoria that are hyphal structures intimately associated with host-plant cell membranes.
Mingsheng Qi, James P. Grayczyk, Janina M. Seitz, Youngsill Lee, Tobias I. Link, Doil Choi, Kerry F. Pedley, Ralf T. Voegele, Thomas J. Baum, Steven A. Whitham   +9 more
doaj   +1 more source

Leaping into the Unknown World of Sporisorium scitamineum Candidate Effectors

Journal of Fungi, 2020
Sporisorium scitamineum is a biotrophic fungus causing sugarcane smut disease. In this study, we set up a pipeline and used genomic and dual transcriptomic data previously obtained by our group to identify candidate effectors of S.
Natália Sousa Teixeira-Silva, Patrícia Dayane Carvalho Schaker, Hugo Vianna Silva Rody, Thiago Maia, Christopher M. Garner, Walter Gassmann, Claudia Barros Monteiro-Vitorello   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source