Results 81 to 90 of about 2,174,249 (299)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

BipC, a Predicted Burkholderia pseudomallei Type 3 Secretion System Translocator Protein with Actin Binding Activity

Frontiers in Cellular and Infection Microbiology, 2017
Burkholderia pseudomallei is an intracellular bacterial pathogen and the causative agent of melioidosis, a severe disease of humans and animals. Like other clinically important Gram-negative bacteria, fundamental to B.
Charles W. Vander Broek, Nurhamimah Zainal Abidin, Joanne M. Stevens   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system [PDF]

, 2011
The intestinal immune system and the epithelium are the first line of defense in the gut. Constantly exposed to microorganisms from the environment, the gut has complex defense mechanisms to prevent infections, as well as regulatory pathways to tolerate ...
Anna Vossenkämper, Thomas T MacDonald, Marches, O, Vossenkamper, A, Olivier Marchès, MacDonald, TT   +5 more
core   +1 more source

Allosteric communication occurs via networks of tertiary and quaternary motions in proteins.

PLoS Computational Biology, 2009
Allosteric proteins bind an effector molecule at one site resulting in a functional change at a second site. We hypothesize that allosteric communication in proteins relies upon networks of quaternary (collective, rigid-body) and tertiary (residue ...
Michael D Daily, Jeffrey J Gray
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Express your LOV: an engineered flavoprotein as a reporter for protein expression and purification [PDF]

, 2012
In this work, we describe the utility of Light, Oxygen, or Voltage-sensing (LOV) flavoprotein domains from plant phototropins as a reporter for protein expression and function.
Jayde A Gawthorne, Akpunarlieva, S.N., John M. Christie (107410), Beckham, K.S.H., Gabrielsen, M., Katherine S. H. Beckham (107407), Alto, Neal M., Alto, N.M., Christie, J.M., Snezhana N. Akpunarlieva (107403), Jayde A. Gawthorne (107393), Mads Gabrielsen (107416), Reddick, L.E., Akpunarlieva, Snezhana N., Jayde A. Gawthorne, Roe, A.J., Katherine S H Beckham, Christie, John M., Snezhana N. Akpunarlieva, L. Evan Reddick (107398), Beckham, Katherine S. H., Mads Gabrielsen, Andrew J Roe, John M Christie, Gabrielsen, Mads, Gawthorne, J.A., Reddick, L. Evan, Andrew J. Roe, Neal M. Alto (107413), John M. Christie, L. Evan Reddick, Snezhana N Akpunarlieva, Neal M. Alto, Andrew J. Roe (107419), Neal M Alto, Roe, Andrew J., Katherine S. H. Beckham, L Evan Reddick, Gawthorne, Jayde A., Christie John M., Akpunarlieva Snezhana N., Roe Andrew J., Gawthorne Jayde A., Beckham Katherine S. H., Gabrielsen Mads, Alto Neal M., Reddick L. Evan   +46 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Annotation of predicted effector proteins of R. necatrix strain R18. [PDF]

Annotation of predicted effector proteins of R. necatrix strain R18.
Petti, Gabriella C., Carlos J. López-Herrera (6598928), López-Moral, Ana, López-Herrera, Carlos, Bart P. H. J. Thomma (9017105), García-Velasco, Rómulo, Rómulo García-Velasco (17810880), Seidl, Michael F., Wilko Punt (17810874), David E. Torres (17810862), Torres, David E., Michael F. Seidl (221772), Wieneke, Jan, Snelders, Nick C., Anton Kraege (17810865), Gabriella C. Petti (17810871), Nick C. Snelders (17810859), Edgar A. Chavarro-Carrero (17810856), Jan Wieneke (17810877), Thomma, Bart P. H. J., Kraege, Anton, Ana López-Moral (17810868), Chavarro-Carrero, Edgar A., Punt, Wilko   +23 more
core   +1 more source

M. incognita candidate effector proteins

, 2020
Accession numbers of M. incognita candidate effectors. These proteins are predicted to be secreted based on the presence of a signal peptide for secretion and absence of transmembrane domains.
Danchin, Etienne
core   +1 more source