Results 161 to 170 of about 402,077 (284)

The Recognition of YopJ Family Effectors Depends on ZAR1/JIM2 Immune Complex in Nicotiana benthamiana. [PDF]

Mol Plant Pathol
Kim I, Kim J, Ahn YJ, Sohn KH, Segonzac C.   +4 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Editorial: Secretomics: More Secrets to Unravel on Plant-Fungus Interactions

Frontiers in Plant Science, 2020
Jan Schirawski, Maryam Rafiqi, Dominique Job, Martijn Rep, Delphine Vincent   +4 more
doaj   +1 more source

Take control of expression: effector-mediated modulation of the host transcriptional machinery. [PDF]

Front Plant Sci
Zuo W, Xiao M, Doehlemann G.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Diversify and conquer: How effector diversity is shaped by host-microbe co-evolution. [PDF]

PLoS Pathog
Müller MC, Brumm S, Hu Y, Kemen E, Lahaye T, Hückelhoven R.   +5 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation. [PDF]

Nat Microbiol
Young V, Dohai B, Halder H, Fernandez-Macgregor J, van Heusden NS, Hitch TCA, Weller B, Hyden P, Saha D, Pieren DKJ, Rittchen S, Lambourne L, Maseko SB, Lin CW, Tun YM, Bibus J, Pletschacher L, Boujeant M, Choteau SA, Bergogne L, Perrin J, Ober F, Schwehn P, Rothballer ST, Altmann M, Altmann S, Strobel A, Rothballer M, Tofaute M, Kotlarz D, Heinig M, Clavel T, Calderwood MA, Vidal M, Twizere JC, Vincentelli R, Krappmann D, Boes M, Falter C, Rattei T, Brun C, Zanzoni A, Falter-Braun P.   +42 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Transmembrane effector substrates of type IV secretion systems: mechanisms of secretion and insertion into host cell membranes. [PDF]

Microlife
Trenz SM, Kuwertz AK, Carl J, Wagner S.
europepmc   +1 more source