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Efferocytosis and Its Role in Inflammatory Disorders [PDF]

Frontiers in Cell and Developmental Biology, 2022
Efferocytosis is the effective clearance of apoptotic cells by professional and non-professional phagocytes. The process is mechanically different from other forms of phagocytosis and involves the localization, binding, internalization, and degradation of apoptotic cells.
Yun Ge, Man Huang, Yong-Ming Yao
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What’s the deal with efferocytosis and asthma?

Trends in Immunology, 2021
Mucosal sites, such as the lung, serve as crucial, yet vulnerable barriers to environmental insults such as pathogens, allergens, and toxins. Often, these exposures induce massive infiltration and death of short-lived immune cells in the lung, and efficient clearance of these cells is important for preventing hyperinflammation and resolving ...
Jennifer, Martinez, Donald N, Cook
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Effect of diabetes on efferocytosis process

Molecular Biology Reports, 2022
Diabetes is a complex of genetic, metabolic, and autoimmune disorders that are characterized by hyperglycemia. Elevated apoptotic cell count following defective clearance of dead cells that can cause chronic inflammation is a hallmark of the diabetic wound. Effective dead cell clearance is a prerequisite for rapid inflammation resolution and successful
Ali Mahmoudi, Ali Ahmadizad firouzjaei, Fatemeh darijani, Jamshid Gholizadeh Navashenaq, Eskandar Taghizadeh, Majid Darroudi, Seyed Mohammad Gheibihayat   +6 more
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Interplay between efferocytosis and atherosclerosis

Archives of Cardiovascular Diseases, 2023
In an adult human, billions of cells die and turn over daily. During this process, many apoptotic cells are produced and subsequently cleared by phagocytes - a process termed efferocytosis, which plays a critical role in tissue homeostasis. Efferocytosis is an important mechanism in the control of inflammatory processes.
Luc, Rochette, Geoffrey, Dogon, Eve, Rigal, Marianne, Zeller, Yves, Cottin, Catherine, Vergely   +5 more
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Efferocytosis in atherosclerosis

Nature Reviews Cardiology
Cardiovascular disease is the leading cause of death worldwide, and it commonly results from atherosclerotic plaque progression. One of the increasingly recognized drivers of atherosclerosis is dysfunctional efferocytosis, a homeostatic mechanism responsible for the clearance of dead cells and the resolution of inflammation.
Shaunak S. Adkar, Nicholas J. Leeper
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Efferocytosis and Bone Dynamics

Current Osteoporosis Reports
This review summarizes the recently published scientific evidence regarding the role of efferocytosis in bone dynamics and skeletal health.Several types of efferocytes have been identified within the skeleton, with macrophages being the most extensively studied. Efferocytosis is not merely a 'clean-up' process vital for maintaining skeletal homeostasis;
Batoon, Lena, Hawse, John R., McCauley, Laurie K., Weivoda, Megan M., Roca, Hernan   +4 more
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Macrophage efferocytosis in health and disease

Cell Biochemistry and Function, 2023
AbstractCreating cellular homeostasis within a defined tissue typically relates to the processes of apoptosis and efferocytosis. A great example here is cell debris that must be removed to prevent unwanted inflammatory responses and then reduce autoimmunity.
Shokufeh Razi, Javad Yaghmoorian Khojini, Fateme Kargarijam, Susan Panahi, Zahra Tahershamsi, Amir Tajbakhsh, Seyed Mohammad Gheibihayat   +6 more
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Methods for Quantitative Efferocytosis Assays

2023
Efferocytosis, the phagocytic removal of apoptotic cells, is a dynamic process requiring recruitment of numerous regulatory proteins to mediate the uptake, engulfment, and degradation of apoptotic cells. Herein, we describe microscopy-based methods for the enumeration of efferocytic events and characterization of the spatiotemporal dynamics of ...
Nima, Taefehshokr, Bryan, Heit
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Quantitative Efferocytosis Assays

2016
Efferocytosis, the phagocytic removal of apoptotic cells, is a dynamic process requiring recruitment of numerous regulatory proteins to forming efferosomes in a tightly regulated manner. Herein we describe microscopy-based methods for the enumeration of efferocytic events and characterization of the spatiotemporal dynamics of signaling molecule ...
Amanda L, Evans, Jack W D, Blackburn, Charles, Yin, Bryan, Heit   +3 more
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Efferocytosis in Homeostasis

Apoptotic cells are removed by professional and nonprofessional phagocytes via the process of "efferocytosis." Efferocytosis is highly efficient such that accumulation of dead cells is rarely seen in healthy tissues, even though our bodies remove 200-400 billion apoptotic cells daily.
Christian, Maueröder, Caitlin M, Gillis, Kodi S, Ravichandran   +2 more
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