Results 121 to 130 of about 16,803 (230)

Efferocytosis: Current status and future prospects in the treatment of autoimmune diseases

Heliyon
Billions of apoptotic cells are swiftly removed from the human body daily. This clearance process is regulated by efferocytosis, an active anti-inflammatory process during which phagocytes engulf and remove apoptotic cells. However, impaired clearance of
Qianwei Li, Huan Liu, Geng Yin, Qibing Xie   +3 more
doaj   +1 more source

In Vitro Modeling of Age‐Associated Lipid Mediator's Impact on Vascular Biology Following Platelet Concentrate Transfusion

Aging Cell, Volume 25, Issue 4, April 2026.
Age‐associated LPA affects adverse reactions and alters platelet and endothelial biology following platelet concentrate transfusion. Age‐associated LPC, S1P could be involved in adverse reactions, in platelet and endothelium biology following a PC transfusion.
Amelie Prier, Mailys Portier, Chloe Heranney, Nancy Kouadio, Charles‐Antoine Arthaud, Marie‐Ange Eyraud, Marco Heestermans, Justine Bertrand‐Michel, Hind Hamzeh‐Cognasse, Fabrice Cognasse, Anne‐Claire Duchez   +10 more
wiley   +1 more source

‘Candidatus Liberibacter Asiaticus’ Effector SECP8 Subverts Salicylic Acid‐Mediated Citrus Immunity via a Two‐Pronged Impairment of CsTCP15 Dimerization

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2335-2349, April 2026.
ABSTRACT Citrus Huanglongbing (HLB), a devastating disease caused by the unculturable bacterium ‘Candidatus Liberibacter asiaticus’ (CLas), poses a severe threat to global citrus production. CLas secretes effectors to suppress host immune responses and facilitate its colonisation. Previously, the CLas effector SECP8 (CLIBASIA_05330) has been identified
Mingyue Qin, Rongyu Pan, Yaqian Shi, Pan Shen, Yuanjian Qiu, Xuejin Cui, Xuefeng Wang, Changyong Zhou, Shimin Fu   +8 more
wiley   +1 more source

Augmenting the Endogenous RBM3 Response Protects Against Burn‐Induced Acute Kidney Injury by Enhancing Macrophage‐Mediated Resolution of Inflammation

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
This study reveals that augmenting the RNA‐binding protein RBM3 ameliorates burn‐induced acute kidney injury (AKI). RBM3 overexpression reprograms pro‐inflammatory M1 macrophages toward a pro‐resolving M2 phenotype, enhancing their capacity for efferocytosis.
Zhengjie Huang, Zihang Tu, Xiaofan Meng, Zhuojin Yang, Hongbin Zhong, Weiping Hu, Jiyi Huang   +6 more
wiley   +1 more source

The Important Role of Phosphatidylserine, ADAM17, TNF-Alpha, and Soluble MER on Efferocytosis Activity in Central Obesity

Journal of Obesity
Background. Obesity is expected to hinder efferocytosis due to ADAM17-mediated cleavage of the MER tyrosine kinase receptor, producing soluble MER (sMER) that disrupts MERTK binding to cell death markers.
Chandra Agung Purnama, Anna Meiliana, Melisa Intan Barliana, Keri Lestari, Andi Wijaya   +4 more
doaj   +1 more source

Metabolic reprogramming in efferocytosis

Frontiers in Cell and Developmental Biology
Efferocytosis refers to the process by which phagocytes specifically identify and eliminate apoptotic cells. This process is essential for both maintaining tissue homeostasis and suppressing inflammatory responses, as well as facilitating tissue repair.
Yan, Qing, Li, Kuo, Chen, Lu, Wang, Aowei, Xi, Yingying, Xiao, Hui, Yuan, Lei   +6 more
openaire   +2 more sources

Dysregulated Efferocytosis in CAD: TNF-α and TGF-β Silencing Reveals Functional Divergence in M1 and M2 Macrophages

Immuno
Efferocytosis, the process by which macrophages clear apoptotic cells, plays a vital role in maintaining immune homeostasis. This study explores the influence of inflammatory cytokines—tumor necrosis factor-alpha (TNF-α) and transforming growth factor ...
Fatin Najiah Mohd Idrus, Hayat Asaad Hameed Al-Ali, Zahidah Nasuha Mohd Yasin, Maryam Azlan, Rapeah Suppian, See Too Wei Cun, Hoe Chee Hock, Nurul Shuhadah Ahmad, Zurkurnai Yusof, Wan Yus Haniff Wan Isa, Akbar Ali Mohamed Ali, Yvonne-Tee Get Bee   +11 more
doaj   +1 more source

Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury

JCI Insight
Efficient clearance and degradation of apoptotic cardiomyocytes by macrophages (collectively termed efferocytosis) is critical for inflammation resolution and restoration of cardiac function after myocardial ischemia/reperfusion (I/R).
Xiaohong Wang, Wa Du, Yutian Li, Hui-Hui Yang, Yu Zhang, Rubab Akbar, Hannah Morgan, Tianqing Peng, Jing Chen, Sakthivel Sadayappan, Yueh-Chiang Hu, Yanbo Fan, Wei Huang, Guo-Chang Fan   +13 more
doaj   +1 more source

Vitamin B12-Loaded Chitosan Nanoparticles Promote Skeletal Muscle Injury Repair in Aged Rats via Amelioration of Aging-Suppressed Efferocytosis

Biomolecules
Muscle gradually loses its regenerative capacity with aging. Recent evidence highlights age-related immune dysregulation as a key driver of satellite cell dysfunction and reduced muscle regeneration.
Walaa Bayoumie El Gazzar, Amina A. Farag, Heba Bayoumi, Shaimaa E. Radwaan, Lina Abdelhady Mohammed, Hend Elsayed Nasr, Nashwa E. Ahmed, Reham M. Ibrahim, Mahmoud Mostafa, Shimaa K. Mohamed, Dania Abdelhady, Eman E. Elwakeel, Amira M. Badr, Sahar Soliman   +13 more
doaj   +1 more source

Phytochemical-mediated efferocytosis and autophagy in inflammation control

Cell Death Discovery
Efferocytosis, the clearance of apoptotic cells, is a critical process that maintains tissue homeostasis and immune regulation. Defective efferocytosis is linked to the development of chronic inflammatory conditions, including atherosclerosis ...
Asma Vafadar, Amir Tajbakhsh, Fatemeh Hosseinpour-Soleimani, Amir Savardshtaki, Mohammad Hashem Hashempur   +4 more
doaj   +1 more source